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189 results

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Page 1
Showing results for heavily nd
Search for Heavilin ND instead (2 results)
Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure.
Hughes TP, Mauro MJ, Cortes JE, Minami H, Rea D, DeAngelo DJ, Breccia M, Goh YT, Talpaz M, Hochhaus A, le Coutre P, Ottmann O, Heinrich MC, Steegmann JL, Deininger MWN, Janssen JJWM, Mahon FX, Minami Y, Yeung D, Ross DM, Tallman MS, Park JH, Druker BJ, Hynds D, Duan Y, Meille C, Hourcade-Potelleret F, Vanasse KG, Lang F, Kim DW. Hughes TP, et al. N Engl J Med. 2019 Dec 12;381(24):2315-2326. doi: 10.1056/NEJMoa1902328. N Engl J Med. 2019. PMID: 31826340 Free PMC article. Clinical Trial.
The median follow-up was 14 months. RESULTS: Patients were heavily pretreated; 70% (105 of 150 patients) had received at least three TKIs. The maximum tolerated dose of asciminib was not reached. ...Common adverse events included fatigue, headache, arthralgia, hypertension …
The median follow-up was 14 months. RESULTS: Patients were heavily pretreated; 70% (105 of 150 patients) had received at least three …
Using the Progression Independent of Relapse Activity Framework to Unveil the Pathobiological Foundations of Multiple Sclerosis.
Ciccarelli O, Barkhof F, Calabrese M, De Stefano N, Eshaghi A, Filippi M, Gasperini C, Granziera C, Kappos L, Rocca MA, Rovira À, Sastre-Garriga J, Sormani MP, Tur C, Toosy AT; as the MAGNIMS Study Group. Ciccarelli O, et al. Neurology. 2024 Jul 9;103(1):e209444. doi: 10.1212/WNL.0000000000209444. Epub 2024 Jun 18. Neurology. 2024. PMID: 38889384 Free PMC article. Review.
PIRA is commonly assessed using Expanded Disability Status Scale, a scale heavily weighted toward motor disability, whereas a more granular assessment of disability deterioration, including cognitive decline, using composite measures or other tools, such as digital tools, …
PIRA is commonly assessed using Expanded Disability Status Scale, a scale heavily weighted toward motor disability, whereas a more gr …
Trends in Biological Ammonia Production.
Adeniyi A, Bello I, Mukaila T, Sarker NC, Hammed A. Adeniyi A, et al. BioTech (Basel). 2023 May 19;12(2):41. doi: 10.3390/biotech12020041. BioTech (Basel). 2023. PMID: 37218758 Free PMC article. Review.
Food production heavily depends on ammonia-containing fertilizers to improve crop yield and profitability. ...
Food production heavily depends on ammonia-containing fertilizers to improve crop yield and profitability. ...
Effector Identification in Plant Pathogens.
Lovelace AH, Dorhmi S, Hulin MT, Li Y, Mansfield JW, Ma W. Lovelace AH, et al. Phytopathology. 2023 Apr;113(4):637-650. doi: 10.1094/PHYTO-09-22-0337-KD. Epub 2023 Apr 26. Phytopathology. 2023. PMID: 37126080 Free article. Review.
A foundation of this research is robust identification of the effector repertoire from a given pathogen, which depends heavily on bioinformatic prediction. In this review, we summarize methodologies that have been used for effector mining in various microbial pathogens whi …
A foundation of this research is robust identification of the effector repertoire from a given pathogen, which depends heavily on bio …
Highly prevalent geriatric medications and their effect on β-amyloid fibril formation.
Zaman Z, Islam R, Koganti B, Falki V, Osentoski T, Graham S, Sharoar MG. Zaman Z, et al. BMC Neurol. 2024 Nov 14;24(1):445. doi: 10.1186/s12883-024-03930-7. BMC Neurol. 2024. PMID: 39543530 Free PMC article.
In the present study, we aimed to analyze the medication profiles of Alzheimer's disease (AD; n = 124), mild cognitive impairment (MCI; n = 114), and non-demented (ND; n = 228) patients to identify highly prevalent drugs and to determine the effects of those drugs on Abeta …
In the present study, we aimed to analyze the medication profiles of Alzheimer's disease (AD; n = 124), mild cognitive impairment (MCI; n = …
Inflammation in Asthma: Mechanistic Insights and the Role of Biologics in Therapeutic Frontiers.
Reza MI, Ambhore NS. Reza MI, et al. Biomedicines. 2025 May 30;13(6):1342. doi: 10.3390/biomedicines13061342. Biomedicines. 2025. PMID: 40564060 Free PMC article. Review.
In this variant, the immune response is heavily driven by eosinophils, mast cells, and T-helper 2 (Th2) cells. These components release a cascade of cytokines, including interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13). ...Among asthmatic patients, ap …
In this variant, the immune response is heavily driven by eosinophils, mast cells, and T-helper 2 (Th2) cells. These components relea …
Laser balloon angioplasty.
Cheong WF, Spears JR, Welch AJ. Cheong WF, et al. Crit Rev Biomed Eng. 1991;19(2-3):113-46. Crit Rev Biomed Eng. 1991. PMID: 1769239 Review.
Unlike conventional transluminal percutaneous angioplasty (PTCA), which applies only intraluminal pressure, laser balloon angioplasty (LBA) employs simultaneous heat and pressure to reopen heavily occluded arterial lumens. The circumferential irradiation of Nd:YAG ( …
Unlike conventional transluminal percutaneous angioplasty (PTCA), which applies only intraluminal pressure, laser balloon angioplasty (LBA) …
Targeted Nanobody-Based Molecular Tracers for Nuclear Imaging and Image-Guided Surgery.
Debie P, Devoogdt N, Hernot S. Debie P, et al. Antibodies (Basel). 2019 Jan 11;8(1):12. doi: 10.3390/antib8010012. Antibodies (Basel). 2019. PMID: 31544818 Free PMC article. Review.
Nanobody-based tracers using either nuclear or fluorescent labels have been heavily investigated preclinically and are currently making their way into the clinic. ...
Nanobody-based tracers using either nuclear or fluorescent labels have been heavily investigated preclinically and are currently maki …
The T cell receptor β chain repertoire of tumor infiltrating lymphocytes improves neoantigen prediction and prioritization.
Pham TMQ, Nguyen TN, Tran Nguyen BQ, Diem Tran TP, Diem Pham NM, Phuc Nguyen HT, Cuong Ho TK, Linh Nguyen DV, Nguyen HT, Tran DH, Tran TS, Pham TVN, Le MT, Vy Nguyen TT, Phan MD, Giang H, Nguyen HN, Tran LS. Pham TMQ, et al. Elife. 2024 Oct 28;13:RP94658. doi: 10.7554/eLife.94658. Elife. 2024. PMID: 39466298 Free PMC article.
Traditionally, this selection process has heavily relied on predicting the binding of peptides to human leukocyte antigens (pHLA). ...
Traditionally, this selection process has heavily relied on predicting the binding of peptides to human leukocyte antigens (pHLA). .. …
Current Immunotherapy Treatments of Primary Breast Cancer Subtypes.
Brown SR, Vomhof-DeKrey EE. Brown SR, et al. Biomedicines. 2024 Apr 18;12(4):895. doi: 10.3390/biomedicines12040895. Biomedicines. 2024. PMID: 38672249 Free PMC article. Review.
Nevertheless, this malignancy remains the most diagnosed cancer among women and relies heavily on a neoadjuvant treatment regimen of chemotherapy and targeted therapy. After standard treatment, 25-30% of breast cancer patients still develop disease recurrence and must unde …
Nevertheless, this malignancy remains the most diagnosed cancer among women and relies heavily on a neoadjuvant treatment regimen of …
189 results