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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Abbracchio MP, Abraham G, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dent G, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Herr D, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Larhammar D, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Lolait SJ, Lupp A, Macrae R, Maguire J, … See abstract for full author list ➔ Alexander SPH, et al. Among authors: holliday nd. Br J Pharmacol. 2023 Oct;180 Suppl 2:S23-S144. doi: 10.1111/bph.16177. Br J Pharmacol. 2023. PMID: 38123151 Free article.
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity.
Motso A, Pelcman B, Kalinovich A, Kahlous NA, Bokhari MH, Dehvari N, Halleskog C, Waara E, de Jong J, Cheesman E, Kallenberg C, Yakala GK, Murad P, Wetterdal E, Andersson P, van Beek S, Sandström A, Alleluia DN, Talamonti E, Youhanna S, Sabatier P, Koenig C, Willems S, Kemas AM, Hutchinson DS, Ham S, Grätz L, Voss J, Marchan-Alvarez JG, Priede M, Jaunsleine K, Spura J, Kovada V, Supe L, Stoddart LA, Holliday ND, Newton PT, Pillon NJ, Schulte G, Summers RJ, Mutule I, Suna E, Olsen JV, Molenaar P, Carlsson J, Lauschke VM, Wright SC, Bengtsson T. Motso A, et al. Among authors: holliday nd. Cell. 2025 Sep 18;188(19):5142-5156.e23. doi: 10.1016/j.cell.2025.05.042. Epub 2025 Jun 23. Cell. 2025. PMID: 40555230 Free article.
High-throughput kinetics in drug discovery.
Pinto MF, Sirina J, Holliday ND, McWhirter CL. Pinto MF, et al. Among authors: holliday nd. SLAS Discov. 2024 Jul;29(5):100170. doi: 10.1016/j.slasd.2024.100170. Epub 2024 Jul 3. SLAS Discov. 2024. PMID: 38964171 Free article. Review.
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity.
Motso A, Pelcman B, Kalinovich A, Kahlous NA, Bokhari MH, Dehvari N, Halleskog C, Waara E, de Jong J, Cheesman E, Kallenberg C, Yakala GK, Murad P, Wetterdal E, Andersson P, van Beek S, Sandström A, Alleluia DN, Talamonti E, Youhanna S, Sabatier P, Koenig C, Willems S, Kemas AM, Hutchinson DS, Ham S, Grätz L, Voss J, Marchan-Alvarez JG, Priede M, Jaunsleine K, Spura J, Kovada V, Supe L, Stoddart LA, Holliday ND, Newton PT, Pillon NJ, Schulte G, Summers RJ, Mutule I, Suna E, Olsen JV, Molenaar P, Carlsson J, Lauschke VM, Wright SC, Bengtsson T. Motso A, et al. Among authors: holliday nd. Cell. 2025 Sep 18;188(19):5429-5431. doi: 10.1016/j.cell.2025.08.022. Epub 2025 Aug 29. Cell. 2025. PMID: 40882626 Free article. No abstract available.
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis.
Talamonti E, Davegardh J, Kalinovich A, van Beek SMM, Dehvari N, Halleskog C, Bokhari HM, Hutchinson DS, Ham S, Humphrys LJ, Dijon NC, Motso A, Sandstrom A, Zacharewicz E, Mutule I, Suna E, Spura J, Ditrychova K, Stoddart LA, Holliday ND, Wright SC, Lauschke VM, Nielsen S, Scheele C, Cheesman E, Hoeks J, Molenaar P, Summers RJ, Pelcman B, Yakala GK, Bengtsson T. Talamonti E, et al. Among authors: holliday nd. Mol Metab. 2024 Jul;85:101931. doi: 10.1016/j.molmet.2024.101931. Epub 2024 May 17. Mol Metab. 2024. PMID: 38796310 Free PMC article.
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM, Bathgate R, Beaulieu JM, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Csaba Z, Dahlgren C, Dent G, Singh KD, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Williams TL, Lolait SJ, Lupp A, Macrae R, Maguire J, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac… See abstract for full author list ➔ Alexander SP, et al. Among authors: holliday nd. Br J Pharmacol. 2021 Oct;178 Suppl 1:S27-S156. doi: 10.1111/bph.15538. Br J Pharmacol. 2021. PMID: 34529832 Free article.
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