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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1966 1
1967 1
1969 1
1971 1
1972 1
1973 1
1975 1
1976 1
1977 2
1978 3
1979 3
1980 5
1981 4
1982 6
1983 2
1984 3
1985 1
1986 3
1987 4
1988 1
1989 9
1990 5
1991 9
1992 11
1993 10
1994 12
1995 13
1996 18
1997 18
1998 12
1999 10
2000 21
2001 15
2002 18
2003 23
2004 15
2005 24
2006 22
2007 18
2008 22
2009 30
2010 25
2011 37
2012 45
2013 47
2014 59
2015 82
2016 61
2017 46
2018 40
2019 44
2020 28
2021 35
2022 38
2023 49
2024 65
2025 31

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1,047 results

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Page 1
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.
Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors. Jack CR Jr, et al. Among authors: holtzman dm. Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018. Alzheimers Dement. 2018. PMID: 29653606 Free PMC article. Review.
Hallmarks of neurodegenerative diseases.
Wilson DM 3rd, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I. Wilson DM 3rd, et al. Among authors: holtzman dm. Cell. 2023 Feb 16;186(4):693-714. doi: 10.1016/j.cell.2022.12.032. Cell. 2023. PMID: 36803602 Free article. Review.
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipelto M, Lista S, Molinuevo JL, O'Bryant SE, Rabinovici GD, Rowe C, Salloway S, Schneider LS, Sperling R, Teichmann M, Carrillo MC, Cummings J, Jack CR Jr; Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclinical State of AD”; July 23, 2015; Washington DC, USA. Dubois B, et al. Among authors: holtzman dm. Alzheimers Dement. 2016 Mar;12(3):292-323. doi: 10.1016/j.jalz.2016.02.002. Alzheimers Dement. 2016. PMID: 27012484 Free PMC article. Review.
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.
Chen X, Firulyova M, Manis M, Herz J, Smirnov I, Aladyeva E, Wang C, Bao X, Finn MB, Hu H, Shchukina I, Kim MW, Yuede CM, Kipnis J, Artyomov MN, Ulrich JD, Holtzman DM. Chen X, et al. Among authors: holtzman dm. Nature. 2023 Mar;615(7953):668-677. doi: 10.1038/s41586-023-05788-0. Epub 2023 Mar 8. Nature. 2023. PMID: 36890231 Free PMC article.
TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.
Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, Lei T, Hou J, Cai Z, Cella M, Nguyen K, Poliani PL, Beatty WL, Chen Y, Cao S, Lin K, Rodrigues C, Ellebedy AH, Gilfillan S, Brown GD, Holtzman DM, Brioschi S, Colonna M. Wang S, et al. Among authors: holtzman dm. Cell. 2022 Oct 27;185(22):4153-4169.e19. doi: 10.1016/j.cell.2022.09.033. Cell. 2022. PMID: 36306735 Free PMC article.
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. Tcw J, et al. Among authors: holtzman dm. Cell. 2022 Jun 23;185(13):2213-2233.e25. doi: 10.1016/j.cell.2022.05.017. Cell. 2022. PMID: 35750033 Free PMC article.
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice.
Parhizkar S, Gent G, Chen Y, Rensing N, Gratuze M, Strout G, Sviben S, Tycksen E, Zhang Q, Gilmore PE, Sprung R, Malone J, Chen W, Remolina Serrano J, Bao X, Lee C, Wang C, Landsness E, Fitzpatrick J, Wong M, Townsend R, Colonna M, Schmidt RE, Holtzman DM. Parhizkar S, et al. Among authors: holtzman dm. Sci Transl Med. 2023 Apr 26;15(693):eade6285. doi: 10.1126/scitranslmed.ade6285. Epub 2023 Apr 26. Sci Transl Med. 2023. PMID: 37099634 Free PMC article.
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy.
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS; Dominantly Inherited Alzheimer Network; Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J. Da Mesquita S, et al. Among authors: holtzman dm. Nature. 2021 May;593(7858):255-260. doi: 10.1038/s41586-021-03489-0. Epub 2021 Apr 28. Nature. 2021. PMID: 33911285 Free PMC article.
1,047 results