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The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial.
Ma L, Hu X, Song L, Chen X, Ouyang M, Billot L, Li Q, Malavera A, Li X, Muñoz-Venturelli P, de Silva A, Thang NH, Wahab KW, Pandian JD, Wasay M, Pontes-Neto OM, Abanto C, Arauz A, Shi H, Tang G, Zhu S, She X, Liu L, Sakamoto Y, You S, Han Q, Crutzen B, Cheung E, Li Y, Wang X, Chen C, Liu F, Zhao Y, Li H, Liu Y, Jiang Y, Chen L, Wu B, Liu M, Xu J, You C, Anderson CS; INTERACT3 Investigators. Ma L, et al. Lancet. 2023 Jul 1;402(10395):27-40. doi: 10.1016/S0140-6736(23)00806-1. Epub 2023 May 25. Lancet. 2023. PMID: 37245517 Free PMC article. Clinical Trial.
Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study.
Hu X, Ouyang M, Xu J, Liu Y, Li X, Jiang Y, Chen X, Billot L, Li MBiostat Q, Malavera A, Venturelli PMO, de Silva A, Thang NH, Wahab KW, Pandian JD, Wasay M, Pontes-Neto OM, Abanto C, Arauz A, Li Z, Chen M, Wang X, Yang C, Xin X, Jiang D, Zheng J, Yu Z, Xiao A, Tao C, Chen L, Wu B, Li H, Anderson CS, You C, Song L, Ma L; INTERACT3 Investigators. Hu X, et al. Lancet Reg Health West Pac. 2025 Aug 28;62:101669. doi: 10.1016/j.lanwpc.2025.101669. eCollection 2025 Sep. Lancet Reg Health West Pac. 2025. PMID: 40927652 Free PMC article.
INTEnsive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3): study protocol for a pragmatic stepped-wedge cluster-randomized controlled trial.
Song L, Hu X, Ma L, Chen X, Ouyang M, Billot L, Li Q, Muñoz-Venturelli P, Abanto C, Pontes-Neto OM, Antonio A, Wasay M, Silva A, Thang NH, Pandian JD, Wahab KW, You C, Anderson CS; INTERACT3 investigators. Song L, et al. Trials. 2021 Dec 20;22(1):943. doi: 10.1186/s13063-021-05881-7. Trials. 2021. PMID: 34930428 Free PMC article.
Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial.
Ouyang M, Anjum A, Mc Cawley FG, Wasay M, Ma L, Hu X, Chen X, Malavera A, Li X, Venturelli PM, Silva HA, Thang NH, Wahab KW, Pandian JD, Pontes-Neto OM, Abanto C, Cano-Nigenda V, Arauz A, You C, Jan S, Song L, Anderson CS, Liu H; INTERACT3 Investigators. Ouyang M, et al. PLOS Glob Public Health. 2024 Dec 19;4(12):e0003711. doi: 10.1371/journal.pgph.0003711. eCollection 2024. PLOS Glob Public Health. 2024. PMID: 39700102 Free PMC article.
Predictive Accuracy of Clinicians Estimates of Death and Recovery after Acute Intracerebral Hemorrhage: Pre-Specified Analysis in INTERACT3 Study.
Song L, Ouyang M, Ma L, Chen X, Wang X, Billot L, Li Q, Malavera A, Li X, Muñoz-Venturelli P, Silva A, Nguyen TH, Wahab KW, Pandian JD, Wasay M, Pontes-Neto OM, Abanto C, Arauz A, You C, Hu X, Song L, Anderson CS; INTERACT3 Investigators. Song L, et al. Cerebrovasc Dis. 2025;54(5):656-663. doi: 10.1159/000541985. Epub 2024 Oct 21. Cerebrovasc Dis. 2025. PMID: 39433033 Clinical Trial.
Mediation Analysis to Identify Individual Component Effects of the Care Bundle to Improve Functional Outcome After ICH in the INTERACT3 Study.
Ren X, Li Q, Ouyang M, Billot L, Chen X, Venturelli PM, de Silva A, Nguyen TH, Wahab KW, Pandian JD, Wasay M, Pontes-Neto OM, Abanto C, Arauz A, You C, Ma L, Hu X, Anderson C, Wang X, Song L; as the INTERACT3 Investigators. Ren X, et al. Neurology. 2025 Oct;105(7):e214070. doi: 10.1212/WNL.0000000000214070. Epub 2025 Sep 12. Neurology. 2025. PMID: 40939125 Clinical Trial.