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Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials.
Majoie CB, Cavalcante F, Gralla J, Yang P, Kaesmacher J, Treurniet KM, Kappelhof M, Yan B, Suzuki K, Zhang Y, Li F, Morimoto M, Zhang L, Miao Z, Rinkel LA, Huang J, Otsuka T, Wang S, Davis S, Cognard C, Hong B, Coutinho JM, Song J, Chen W, Emmer BJ, Eker O, Zhang L, Dobrocky T, Nguyen HT, Bush S, Peng Y, LeCouffe NE, Takeuchi M, Han H, Matsumaru Y, Strbian D, Lingsma HF, Nieboer D, Yang Q, Meinel T, Mitchell P, Kimura K, Zi W, Nogueira RG, Liu J, Roos YB, Fischer U; IRIS collaborators. Majoie CB, et al. Lancet. 2023 Sep 16;402(10406):965-974. doi: 10.1016/S0140-6736(23)01142-X. Epub 2023 Aug 25. Lancet. 2023. PMID: 37640037
Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis.
Kaesmacher J, Cavalcante F, Kappelhof M, Treurniet KM, Rinkel L, Liu J, Yan B, Zi W, Kimura K, Eker OF, Zhang Y, Piechowiak EI, van Zwam W, Liu S, Strbian D, Uyttenboogaart M, Dobrocky T, Miao Z, Suzuki K, Zhang L, van Oostenbrugge R, Meinel TR, Guo C, Seiffge D, Yin C, Bütikofer L, Lingsma H, Nieboer D, Yang P, Mitchell P, Majoie C, Fischer U, Roos Y, Gralla J; IRIS Collaborators. Kaesmacher J, et al. JAMA. 2024 Mar 5;331(9):764-777. doi: 10.1001/jama.2024.0589. JAMA. 2024. PMID: 38324409 Free PMC article.
Intravenous thrombolysis before endovascular treatment versus endovascular treatment alone for patients with large vessel occlusion and carotid tandem lesions: individual participant data meta-analysis of six randomised trials.
Cavalcante F, Treurniet K, Kaesmacher J, Kappelhof M, Rohner R, Yang P, Liu J, Suzuki K, Yan B, van Elk T, Zhang L, Uyttenboogaart M, Zi W, Imad D, Zhang Y, Chrysanthi P, Rice H, Xing P, Kimura K, Mitchel P, Bücke P, Guo C, Costalat V, Bourcier R, Nieboer D, Lingsma H, Gralla J, Fischer U, Roos YB, Majoie CB; IRIS collaborators. Cavalcante F, et al. Lancet Neurol. 2025 Apr;24(4):305-315. doi: 10.1016/S1474-4422(25)00045-6. Lancet Neurol. 2025. PMID: 40120615
Intracranial Hemorrhage in Patients With Stroke After Endovascular Treatment With or Without IV Alteplase: An Individual Participant Data Meta-Analysis.
Zhou Y, Zhang L, Cavalcante F, Suzuki K, Treurniet KM, Yan B, Mitchell P, Bush S, Fischer U, Kaesmacher J, Gralla J, Strbian D, Rohner R, Kappelhof M, Roos Y, Majoie C, Zi W, Yang Q, Zhang Y, Matsumaru Y, Kimura K, Ye X, Yang P, Liu J; IRIS collaborators. Zhou Y, et al. JAMA Neurol. 2025 Aug 11:e252610. doi: 10.1001/jamaneurol.2025.2610. Online ahead of print. JAMA Neurol. 2025. PMID: 40788598