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Page 1
Showing results for heme oc
Search for Iheme OC instead (1 results)
Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe2+ accumulation.
Ni M, Zhou J, Zhu Z, Xu Q, Yin Z, Wang Y, Zheng Z, Zhao H. Ni M, et al. Phytomedicine. 2023 Apr;112:154701. doi: 10.1016/j.phymed.2023.154701. Epub 2023 Feb 4. Phytomedicine. 2023. PMID: 36773431
At present, the synergistic effects and mechanism of combination of shikonin and cisplatin to overcome cisplatin resistance in OC are still unknown. PURPOSE: This study was to evaluate the synergistic effects of shikonin and cisplatin on cisplatin-resistant OC cells …
At present, the synergistic effects and mechanism of combination of shikonin and cisplatin to overcome cisplatin resistance in OC are …
Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation.
Qiu H, Jin H, Miao J, Li H, Chen J, Yang X, Chen X, Mullin BH, Chen K, Gu R, Qin A, Wilson SG, Xu J. Qiu H, et al. J Bone Miner Res. 2025 May 24;40(5):639-655. doi: 10.1093/jbmr/zjaf040. J Bone Miner Res. 2025. PMID: 40073838 Free PMC article.
Collectively, we found that RANKL-mediated signaling regulated mitochondrial formation and heme metabolism to synergistically support osteoclastogenesis. Inhibition of heme synthesis impaired OC formation and reversed excessive bone loss, representing a new t …
Collectively, we found that RANKL-mediated signaling regulated mitochondrial formation and heme metabolism to synergistically support …
Effects of virtual reality-based motor control training on inflammation, oxidative stress, neuroplasticity and upper limb motor function in patients with chronic stroke: a randomized controlled trial.
Huang CY, Chiang WC, Yeh YC, Fan SC, Yang WH, Kuo HC, Li PC. Huang CY, et al. BMC Neurol. 2022 Jan 11;22(1):21. doi: 10.1186/s12883-021-02547-4. BMC Neurol. 2022. PMID: 35016629 Free PMC article. Clinical Trial.
Serum biomarkers including interleukin 6 (IL-6), intracellular adhesion molecule 1 (ICAM-1), heme oxygenase 1 (HO-1), 8-hydroxy-2-deoxyguanosine (8-OHdG), and brain-derived neurotrophic factor (BDNF) were assessed to reflect inflammation, oxidative stress and neuroplastici …
Serum biomarkers including interleukin 6 (IL-6), intracellular adhesion molecule 1 (ICAM-1), heme oxygenase 1 (HO-1), 8-hydroxy-2-deo …
Exploring the folding energy landscapes of heme proteins using a hybrid AWSEM-heme model.
Chen X, Lu W, Tsai MY, Jin S, Wolynes PG. Chen X, et al. J Biol Phys. 2022 Mar;48(1):37-53. doi: 10.1007/s10867-021-09596-3. Epub 2022 Jan 9. J Biol Phys. 2022. PMID: 35000062 Free PMC article.
Heme is an active center in many proteins. Here we explore computationally the role of heme in protein folding and protein structure. ...In binding the heme, coordinated covalent bonds and thioester covalent bonds for heme c drive the heme towar …
Heme is an active center in many proteins. Here we explore computationally the role of heme in protein folding and protein str …
Heme-bound tyrosine vibrations in hemoglobin M: Resonance Raman, crystallography, and DFT calculation.
Nagatomo S, Shoji M, Terada T, Nakatani K, Shigeta Y, Hirota S, Yanagisawa S, Kubo M, Kitagawa T, Nagai M, Ohki M, Park SY, Shibayama N. Nagatomo S, et al. Biophys J. 2022 Jul 19;121(14):2767-2780. doi: 10.1016/j.bpj.2022.06.012. Epub 2022 Jun 9. Biophys J. 2022. PMID: 35689380 Free PMC article.
Hemoglobins M (Hbs M) are human hemoglobin variants in which either the alpha or beta subunit contains a ferric heme in the alpha(2)beta(2) tetramer. Though the ferric subunit cannot bind O(2), it regulates O(2) affinity of its counterpart ferrous subunit. We have investig …
Hemoglobins M (Hbs M) are human hemoglobin variants in which either the alpha or beta subunit contains a ferric heme in the alpha(2)b …
MicroRNA-183 increases osteoclastogenesis by repressing heme oxygenase-1.
Ke K, Sul OJ, Rajasekaran M, Choi HS. Ke K, et al. Bone. 2015 Dec;81:237-246. doi: 10.1016/j.bone.2015.07.006. Epub 2015 Jul 8. Bone. 2015. PMID: 26163109
We have demonstrated previously that the up-regulation of heme oxygenase-1 (HO-1) attenuated osteoclastogenesis in bone marrow-derived macrophages (BMMs). ...Moreover, the HO-1 inducers, resveratrol and piceatannol decrease the expression of miR-183, resulting in attenuate …
We have demonstrated previously that the up-regulation of heme oxygenase-1 (HO-1) attenuated osteoclastogenesis in bone marrow-derive …
Heme Biosynthetic Gene Expression Analysis With dPCR in Erythropoietic Protoporphyria Patients.
Granata F, Brancaleoni V, Barman-Aksözen J, Scopetti M, De Luca G, Fustinoni S, Motta I, Di Pierro E, Graziadei G. Granata F, et al. Front Physiol. 2022 Jul 18;13:886194. doi: 10.3389/fphys.2022.886194. eCollection 2022. Front Physiol. 2022. PMID: 35923227 Free PMC article.
Background: The heme biosynthesis (HB) involves eight subsequent enzymatic steps. Erythropoietic protoporphyria (EPP) is caused by loss-of-function mutations in the ferrochelatase (FECH) gene, which in the last HB step inserts ferrous iron into protoporphyrin IX (PPIX) to …
Background: The heme biosynthesis (HB) involves eight subsequent enzymatic steps. Erythropoietic protoporphyria (EPP) is caused by lo …
Non-Heme Iron Enzymes Catalyze Heterobicyclic and Spirocyclic Isoquinolone Core Formation in Piperazine Alkaloid Biosynthesis.
Pham MT, Yang FL, Liu IC, Liang PH, Lin HC. Pham MT, et al. Angew Chem Int Ed Engl. 2024 May 13;63(20):e202401324. doi: 10.1002/anie.202401324. Epub 2024 Apr 9. Angew Chem Int Ed Engl. 2024. PMID: 38499463
Their biosynthetic pathway involves two crucial non-heme iron enzymes, ParF and ParG, for core skeleton construction. ParF has a dual function facilitating 2,3-alkene formation of helvamide, as a substrate for ParG, and oxidative cleavage of piperazine. ...
Their biosynthetic pathway involves two crucial non-heme iron enzymes, ParF and ParG, for core skeleton construction. ParF has a dual …
Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics.
Tian X, El-Deiry WS. Tian X, et al. Oncotarget. 2024 Sep 17;15:614-633. doi: 10.18632/oncotarget.28637. Oncotarget. 2024. PMID: 39288289 Free PMC article.
PG3 and PG3-Oc upregulate p21, PUMA, and DR5 in five cancer cell lines with various p53 mutational statuses through ATF4 (Activating Transcriptional Factor 4) and integrated stress response (ISR) independent of p53. ...PG3 treatment activates ATF4 through ISR via kinase HR …
PG3 and PG3-Oc upregulate p21, PUMA, and DR5 in five cancer cell lines with various p53 mutational statuses through ATF4 (Activating …
88 results