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Page 1
Showing results for inos l
Search for Inosi L instead (1 results)
LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
Wei Z, Oh J, Flavell RA, Crawford JM. Wei Z, et al. Nature. 2022 Sep;609(7926):348-353. doi: 10.1038/s41586-022-05111-3. Epub 2022 Aug 17. Nature. 2022. PMID: 35978195 Free PMC article.
Here we elucidated a shared biochemical function of LACC1 in mice and humans, converting L-citrulline to L-ornithine (L-Orn) and isocyanic acid and serving as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism. ...Str …
Here we elucidated a shared biochemical function of LACC1 in mice and humans, converting L-citrulline to L-ornithine (L …
INOS ablation promotes corneal wound healing via activation of Akt signaling.
Sun Z, Lu K, He Q, Tang Y, Li H, Pazo EE, Hu L, Wei R. Sun Z, et al. Exp Eye Res. 2024 Jun;243:109886. doi: 10.1016/j.exer.2024.109886. Epub 2024 Apr 5. Exp Eye Res. 2024. PMID: 38583755
Here, we aimed to investigate the potential mechanisms of nitric oxide (NO) and its mediator, inducible nitric oxide synthase (iNOS), in the process of corneal wound healing. We established a corneal injury model of iNOS(-/-) mice, and treated human corneal epitheli …
Here, we aimed to investigate the potential mechanisms of nitric oxide (NO) and its mediator, inducible nitric oxide synthase (iNOS), …
Elevated iNOS and 3'-nitrotyrosine in Kaposi's Sarcoma tumors and mouse model.
Vladimirova O, Soldan S, Su C, Kossenkov A, Ngalamika O, Tso FY, West JT, Wood C, Lieberman PM. Vladimirova O, et al. Tumour Virus Res. 2023 Jun;15:200259. doi: 10.1016/j.tvr.2023.200259. Epub 2023 Mar 1. Tumour Virus Res. 2023. PMID: 36863485 Free PMC article.
We show that iNOS is highly expressed in the L1T3/mSLK tumor model of KS. iNOS expression correlated with KSHV lytic cycle gene expression, which was elevated in late-stage tumors (>4 weeks) but to a lesser degree in early stage (1 week) xenografts. ...These find …
We show that iNOS is highly expressed in the L1T3/mSLK tumor model of KS. iNOS expression correlated with KSHV lytic cycle gen …
iNOS-mediated nitric oxide production and its regulation.
Aktan F. Aktan F. Life Sci. 2004 Jun 25;75(6):639-53. doi: 10.1016/j.lfs.2003.10.042. Life Sci. 2004. PMID: 15172174 Review.
This review focuses on the production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) and its regulation under physiological and pathophysiological conditions. NO is an important biological mediator in the living organism that is synthesized from L-ar …
This review focuses on the production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) and its regulation under physiol …
L-arginine protects human heart cells from low-volume anoxia and reoxygenation.
Shiono N, Rao V, Weisel RD, Kawasaki M, Li RK, Mickle DA, Fedak PW, Tumiati LC, Ko L, Verma S. Shiono N, et al. Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H805-15. doi: 10.1152/ajpheart.00594.2001. Am J Physiol Heart Circ Physiol. 2002. PMID: 11834473 Free article. Review.
Protective effects of L-arginine were evaluated in a human ventricular heart cell model of low-volume anoxia and reoxygenation independent of alternate cell types. ...In addition, L-arginine cardioprotection was achieved by the activation of guanylate cyclase, leadi …
Protective effects of L-arginine were evaluated in a human ventricular heart cell model of low-volume anoxia and reoxygenation indepe …
Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin.
Lechner M, Lirk P, Rieder J. Lechner M, et al. Semin Cancer Biol. 2005 Aug;15(4):277-89. doi: 10.1016/j.semcancer.2005.04.004. Semin Cancer Biol. 2005. PMID: 15914026 Review.
Inducible nitric oxide synthase (iNOS) is one of three key enzymes generating nitric oxide (NO) from the amino acid l-arginine. iNOS-derived NO plays an important role in numerous physiological (e.g. blood pressure regulation, wound repair and host defence me …
Inducible nitric oxide synthase (iNOS) is one of three key enzymes generating nitric oxide (NO) from the amino acid l-arginine …
L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis.
Coburn LA, Horst SN, Allaman MM, Brown CT, Williams CS, Hodges ME, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT. Coburn LA, et al. Inflamm Bowel Dis. 2016 Aug;22(8):1847-58. doi: 10.1097/MIB.0000000000000790. Inflamm Bowel Dis. 2016. PMID: 27104830 Free PMC article.
BACKGROUND: L-arginine (L-Arg) is the substrate for both inducible nitric oxide (NO) synthase (NOS2) and arginase (ARG) enzymes. ...RESULTS: Dietary intake of arginine and serum L-Arg levels were not different in UC patients versus control subjects. In active …
BACKGROUND: L-arginine (L-Arg) is the substrate for both inducible nitric oxide (NO) synthase (NOS2) and arginase (ARG) enzyme …
L-Citrulline increases nitric oxide and improves control in obese asthmatics.
Holguin F, Grasemann H, Sharma S, Winnica D, Wasil K, Smith V, Cruse MH, Perez N, Coleman E, Scialla TJ, Que LG. Holguin F, et al. JCI Insight. 2019 Dec 19;4(24):e131733. doi: 10.1172/jci.insight.131733. JCI Insight. 2019. PMID: 31714895 Free PMC article. Clinical Trial.
To this end, we recruited obese (BMI >30) asthmatics on controller therapy, with a baseline FeNO of 30 ppb from the University of Colorado Medical Center and Duke University Health System.RESULTSA total of 41 subjects with an average FeNO of 17 ppb (95% CI, 15-19) and poorly c …
To this end, we recruited obese (BMI >30) asthmatics on controller therapy, with a baseline FeNO of 30 ppb from the University of Colorad …
Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.
Hallinan EA, Tsymbalov S, Dorn CR, Pitzele BS, Hansen DW Jr, Moore WM, Jerome GM, Connor JR, Branson LF, Widomski DL, Zhang Y, Currie MG, Manning PT. Hallinan EA, et al. J Med Chem. 2002 Apr 11;45(8):1686-9. doi: 10.1021/jm010420e. J Med Chem. 2002. PMID: 11931623
In contrast to L-NIL, 1 is a stable, nonhygroscopic, crystalline solid. Unlike L-NIL, 1 has minimal inhibitory activity in vitro on human inducible nitric oxide synthase (iNOS). However, it is rapidly converted in vivo to L-NIL and produces dose-depend …
In contrast to L-NIL, 1 is a stable, nonhygroscopic, crystalline solid. Unlike L-NIL, 1 has minimal inhibitory activity in vit …
6,082 results