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Page 1
Showing results for indole a
Search for Inwole A instead (3 results)
Recent progress in biologically active indole hybrids: a mini review.
Mahmoud E, Hayallah AM, Kovacic S, Abdelhamid D, Abdel-Aziz M. Mahmoud E, et al. Pharmacol Rep. 2022 Aug;74(4):570-582. doi: 10.1007/s43440-022-00370-3. Epub 2022 May 20. Pharmacol Rep. 2022. PMID: 35594012 Review.
The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. ...Scientists are therefore interested in the synthesis of biologically active indole-based hybrids such as indole-coumarin, indole-chal …
The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. ...Scientists are …
A Review on Indole-triazole Molecular Hybrids as a Leading Edge in Drug Discovery: Current Landscape and Future Perspectives.
Rohilla S, Goyal G, Berwal P, Mathur N. Rohilla S, et al. Curr Top Med Chem. 2024;24(18):1557-1588. doi: 10.2174/0115680266307132240509065351. Curr Top Med Chem. 2024. PMID: 38766822 Review.
The achievable structural diversity with indole-triazole conjugates offers avenues to optimize their pharmacokinetic and pharmacodynamic attributes, amplifying their therapeutic efficacy. Researchers have extensively tailored both indole and triazole frameworks with …
The achievable structural diversity with indole-triazole conjugates offers avenues to optimize their pharmacokinetic and pharmacodyna …
Anticancer Indole-Based Chalcones: A Structural and Theoretical Analysis.
Badria FA, Soliman SM, Atef S, Islam MS, Al-Majid AM, Dege N, Ghabbour HA, Ali M, El-Senduny FF, Barakat A. Badria FA, et al. Molecules. 2019 Oct 16;24(20):3728. doi: 10.3390/molecules24203728. Molecules. 2019. PMID: 31623155 Free PMC article.
The crystal structures of five new chalcones derived from N-ethyl-3-acetylindole with different substituents were investigated: (E)-3-(4-bromophenyl)-1-(1-ethyl-1H-indol-3-yl)prop-2-en-1-one (3a); (E)-3-(3-bromophenyl)-1-(1-ethyl-1H-indol-3-yl)prop-2-en-1-one (3b); …
The crystal structures of five new chalcones derived from N-ethyl-3-acetylindole with different substituents were investigated: (E)-3-(4-bro …
Activation of the aryl hydrocarbon receptor via indole derivatives is a common feature in skin bacterial isolates.
Elias AE, McBain AJ, Aldehalan FA, Taylor G, O'Neill CA. Elias AE, et al. J Appl Microbiol. 2024 Nov 4;135(11):lxae273. doi: 10.1093/jambio/lxae273. J Appl Microbiol. 2024. PMID: 39444068
The skin microbiota plays a crucial role in maintaining epidermal barrier integrity and is thought to modulate skin homeostasis partly through the production of AhR ligands, including metabolites of microbial tryptophan metabolism such as indole derivatives. Here, we repor …
The skin microbiota plays a crucial role in maintaining epidermal barrier integrity and is thought to modulate skin homeostasis partly throu …
The indole pulse: a new perspective on indole signalling in Escherichia coli.
Gaimster H, Cama J, Hernández-Ainsa S, Keyser UF, Summers DK. Gaimster H, et al. PLoS One. 2014 Apr 2;9(4):e93168. doi: 10.1371/journal.pone.0093168. eCollection 2014. PLoS One. 2014. PMID: 24695245 Free PMC article.
Indole has diverse signalling roles, including modulation of biofilm formation, virulence and stress responses. ...We provide evidence that the pertinent signal in this case is not 1 mM indole in the culture supernatant but a transient pulse of intra-cellular ind …
Indole has diverse signalling roles, including modulation of biofilm formation, virulence and stress responses. ...We provide evidenc …
Synthetic strategies, SAR studies, and computer modeling of indole 2 and 3-carboxamides as the strong enzyme inhibitors: a review.
Chehardoli G, Bahmani A. Chehardoli G, et al. Mol Divers. 2021 Feb;25(1):535-550. doi: 10.1007/s11030-020-10061-x. Epub 2020 May 12. Mol Divers. 2021. PMID: 32394235 Free PMC article. Review.
Indole derivatives have been the focus of many researchers in the study of pharmaceutical compounds for many years. ...It is hoped that indole scaffolds will be tested in the future for maximum activity in pharmacological compounds....
Indole derivatives have been the focus of many researchers in the study of pharmaceutical compounds for many years. ...It is hoped th …
The enol tautomer of indole-3-pyruvic acid as a biological switch in stress responses.
Bartolini B, Corniello C, Sella A, Somma F, Politi V. Bartolini B, et al. Adv Exp Med Biol. 2003;527:601-8. doi: 10.1007/978-1-4615-0135-0_69. Adv Exp Med Biol. 2003. PMID: 15206779 Review.
Indole-3-pyruvic acid (IPA) undergoes in solutions to the keto-enol tautomerism, which appears responsible of its pharmacological effects, as only the enol tautomer is an easy target for oxygen free-radicals and can be transformed directly to kynurenic acid (KYNA). ...
Indole-3-pyruvic acid (IPA) undergoes in solutions to the keto-enol tautomerism, which appears responsible of its pharmacological eff …
Prenylation of a nonaromatic carbon of indolylbutenone by a fungal indole prenyltransferase.
Chen J, Morita H, Wakimoto T, Mori T, Noguchi H, Abe I. Chen J, et al. Org Lett. 2012 Jun 15;14(12):3080-3. doi: 10.1021/ol301129x. Epub 2012 May 30. Org Lett. 2012. PMID: 22642693
FtmPT1 from Aspergillus fumigatus is a fungal indole prenyltransferase (PT) that normally catalyzes the regiospecific prenylation of brevianamide F (cyclo-L-Trp-L-Pro) at the C-2 position of the indole ring with dimethylallyl diphosphate (DMAPP). ...This is the firs …
FtmPT1 from Aspergillus fumigatus is a fungal indole prenyltransferase (PT) that normally catalyzes the regiospecific prenylation of …
A new prenylated indole diketopiperazine alkaloid from Eurotium cristatum.
Zou X, Li Y, Zhang X, Li Q, Liu X, Huang Y, Tang T, Zheng S, Wang W, Tang J. Zou X, et al. Molecules. 2014 Nov 3;19(11):17839-47. doi: 10.3390/molecules191117839. Molecules. 2014. PMID: 25372398 Free PMC article.
A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. ...
A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3) …
Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule.
Okishima A, Koide H, Hoshino Y, Egami H, Hamashima Y, Oku N, Asai T. Okishima A, et al. Biomacromolecules. 2019 Apr 8;20(4):1644-1654. doi: 10.1021/acs.biomac.8b01820. Epub 2019 Mar 15. Biomacromolecules. 2019. PMID: 30848887
The amounts of indole captured by NPs depended on the structures and feed ratios of the hydrophobic monomers and the polymer density but not on the particle size. The combination of hydrophobic and quadrupole interaction was effective to enhance the affinity and specificit …
The amounts of indole captured by NPs depended on the structures and feed ratios of the hydrophobic monomers and the polymer density …
380,400 results
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