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. 1980 Aug 14;286(5774):669-75.
doi: 10.1038/286669a0.

An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing

W Dunnick, T H Rabbitts, C Milstein

An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing

W Dunnick et al. Nature. .

Abstract

The IF2 immunoglobulin mutant is a DNA deletion of one coding segment and large sections of the flanking intervening sequences. The deletion results in a new splicing pattern and starts in a DNA region containing tandemly repeated sequences which may carry heavy-chain class switch signals.

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