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. 1981 Dec 17;294(5842):626-31.
doi: 10.1038/294626a0.

Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements

G Galli, H Hofstetter, M L Birnstiel

Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements

G Galli et al. Nature. .

Abstract

The split promoter sequences of a tRNALeuCUG gene of Xenopus laevis have been mapped to nucleotides 13-20 and 51-64 of the tRNALeu coding sequences. The sequences closely coincide with two conserved sequence blocks present in all eukaryotic tRNA genes. The two conserved sequence blocks were found to be exchangeable between tRNA genes as chimaeric tRNAMet--tRNALeu genes proved transcriptionally active. Furthermore, two prokaryotic tRNA genes exhibiting strong homologies with the two blocks yielded specific transcripts when tested in an eukaryotic transcriptional system.

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