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. 1989 Apr;4(3):362-6.
doi: 10.1016/0888-7543(89)90343-1.

Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32

N C Popescu  1 , C R King, M H Kraus
Affiliations

Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32

N C Popescu et al. Genomics. 1989 Apr.

Abstract

Through the use of a cDNA probe, the human erbB-2 gene was localized by in situ hybridization of normal human chromosomes at 17q11-q21. In situ hybridization of chromosomes derived from fibroblasts carrying a constitutional 15;17t(q22.3;q11.21) translocation showed that the erbB-2 gene was relocated on the rearranged chromosome 15. These results as well as grain localization on prophase chromosomes locate the erbB-2 gene at 17q12-q21.32. This localization may facilitate the search for human malignancies with chromosome changes involving the erbB-2 gene.

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