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. 2014 Mar;30(3):294-8.
doi: 10.1089/AID.2013.0222. Epub 2014 Feb 7.

Prevalence of drug resistance in human immunodeficiency virus type 1-infected treatment-naive children in Pune, India

Mukesh Kumar  1 , Sourav Sen, Rakesh K Gupta, Devidas Chaturbhuj, Srikanth P Tripathy, Ramesh S Paranjape
Affiliations

Prevalence of drug resistance in human immunodeficiency virus type 1-infected treatment-naive children in Pune, India

Mukesh Kumar et al. AIDS Res Hum Retroviruses. 2014 Mar.

Abstract

Abstract We report the presence of drug resistance mutations in 7.4% (2/27) of the treatment-naive, HIV-1-infected children in Pune, India, who had HIV-1 RNA levels >1,000 copies/ml. Nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations, namely A98G and K103N, were observed in two separate sequences. In addition, three study sequences displayed three separate HIV-1 protease minor resistance mutations-L10I, A71T, and T74S. These preliminary data from Pune, India, reporting the presence of HIVDR in treatment-naive, HIV-1-infected children, reinforces the need to conduct large-scale studies to assess the prevalence of primary HIVDR in the pediatric population, which in turn will aid in planning protocols and policies related to antiretroviral treatment for the pediatric population.

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Figures

<b>FIG. 1.</b>
FIG. 1.
Phylogenetic tree constructed by using Mega 5.0 software, using the General Time Reversible (GTR) model and rooted with the M group consensus sequence. The sequences that were included were consensus sequences for the M group, A1, A2, B, C, D, AE, F1, F2, G, H, and K, and the study sequences.
See this image and copyright information in PMC

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