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. 2012 May;18(5):869-72.
doi: 10.3201/eid1805.111712.

Hepatitis E virus infection among solid organ transplant recipients, the Netherlands

Suzan D Pas  1 , Rob A de Man, Claudia Mulders, Aggie H M M Balk, Peter T W van Hal, Willem Weimar, Marion P G Koopmans, Albert D M E Osterhaus, Annemiek A van der Eijk
Affiliations

Hepatitis E virus infection among solid organ transplant recipients, the Netherlands

Suzan D Pas et al. Emerg Infect Dis. 2012 May.

Abstract

We screened 1,200 living heart, lung, liver, and kidney transplant recipients for hepatitis E virus infection by reverse transcription PCR. In 12 (1%) patients, hepatitis E virus infection was identified; in 11 patients, chronic infection developed. This immunocompromised population is at risk for hepatitis E virus infection.

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Figures

Figure
Figure
Phylogenetic tree of hepatitis E virus (HEV) open reading frame (ORF) 1 sequences, including HEV infections, the Netherlands, 2000–2011. Phylogenetic relation of a 306-bp ORF1 region was calculated by using maximum-likelihood, Kimura 2-parameter analysis with bootstrapping (n = 1,000). HEV sequences originating in the Netherlands are indicated as NL with year of isolation and isolate number (GenBank accession nos. JQ015399–JQ015448). Boldface indicates virus strains of chronic HEV-infected solid organ transplant recipients identified in this study. Scale bar indicates number of nucleotide substitutions per site. HTX, heart transplant; NTX, kidney transplant; LTX, liver transplant; lungTX, lung transplant.
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