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32 results

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Page 1
Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite.
Lamers OAC, Franke-Fayard BMD, Koopman JPR, Roozen GVT, Janse JJ, Chevalley-Maurel SC, Geurten FJA, de Bes-Roeleveld HM, Iliopoulou E, Colstrup E, Wessels E, van Gemert GJ, van de Vegte-Bolmer M, Graumans W, Stoter TR, Mordmüller BG, Houlder EL, Bousema T, Murugan R, McCall MBB, Janse CJ, Roestenberg M. Lamers OAC, et al. Among authors: janse jj. N Engl J Med. 2024 Nov 21;391(20):1913-1923. doi: 10.1056/NEJMoa2313892. N Engl J Med. 2024. PMID: 39565990 Clinical Trial.
Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas.
Manurung MD, Sonnet F, Hoogerwerf MA, Janse JJ, Kruize Y, Bes-Roeleveld L, König M, Loukas A, Dewals BG, Supali T, Jochems SP, Roestenberg M, Coppola M, Yazdanbakhsh M. Manurung MD, et al. Among authors: janse jj. Nat Commun. 2024 Jul 16;15(1):5960. doi: 10.1038/s41467-024-50313-0. Nat Commun. 2024. PMID: 39013877 Free PMC article.
Early symptom-associated inflammatory responses shift to type 2 responses in controlled human schistosome infection.
Houlder EL, Stam KA, Koopman JPR, König MH, Langenberg MCC, Hoogerwerf MA, Niewold P, Sonnet F, Janse JJ, Partal MC, Sijtsma JC, de Bes-Roeleveld LHM, Kruize YCM, Yazdanbakhsh M, Roestenberg M. Houlder EL, et al. Among authors: janse jj. Sci Immunol. 2024 Jul 5;9(97):eadl1965. doi: 10.1126/sciimmunol.adl1965. Epub 2024 Jul 5. Sci Immunol. 2024. PMID: 38968336
T cell responses in repeated controlled human schistosome infection compared to natural exposure.
Driciru E, Koopman JPR, Steenbergen S, Sonnet F, Stam KA, Bes-Roeleveld L, Iliopoulou E, Janse JJ, Sijtsma J, Nambuya I, Hilt ST, König M, Kruize Y, Casacuberta-Partal M, Egesa M, van Dam GJ, Corstjens PLAM, van Lieshout L, Mpairwe H, MacDonald AS, Yazdanbakhsh M, Elliott AM, Roestenberg M, Houlder EL. Driciru E, et al. Among authors: janse jj. Nat Commun. 2025 Jul 24;16(1):6827. doi: 10.1038/s41467-025-62144-8. Nat Commun. 2025. PMID: 40707512 Free PMC article. Clinical Trial.
Clinical tolerance but no protective efficacy in a placebo-controlled trial of repeated controlled schistosome infection.
Koopman JPR, Houlder EL, Janse JJ, Lamers OA, Roozen GV, Sijtsma JC, Casacuberta-Partal M, Hilt ST, van der Stoep MYEC, van Amerongen-Westra IM, Brienen EA, Wammes LJ, van Lieshout L, van Dam GJ, Corstjens PL, van Diepen A, Yazdanbakhsh M, Hokke CH, Roestenberg M. Koopman JPR, et al. Among authors: janse jj. J Clin Invest. 2024 Dec 12;135(4):e185422. doi: 10.1172/JCI185422. J Clin Invest. 2024. PMID: 39666392 Free PMC article. Clinical Trial.
Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial.
Roozen GVT, van Schuijlenburg R, Hensen ADO, Koopman JPR, Lamers OAC, Geurten FJA, Sijtsma JC, Baalbergen E, Janse JJ, Chevalley-Maurel S, Naar CM, Bezemer S, Kroeze H, van de Stadt HJF, de Visser B, Meij P, Tihaya MS, Colstrup E, Iliopoulou E, de Bes-Roeleveld HM, Wessels E, van der Stoep MYEC, Janse CJ, Murugan R, Franke-Fayard BMD, Roestenberg M. Roozen GVT, et al. Among authors: janse jj. Nat Med. 2025 Jan;31(1):218-222. doi: 10.1038/s41591-024-03347-2. Epub 2025 Jan 3. Nat Med. 2025. PMID: 39753962 Free PMC article. Clinical Trial.
Urinary Metabolic Profiling in Volunteers Undergoing Malaria Challenge in Gabon.
Betouke Ongwe ME, Kohler I, Manurung MD, Verhoeven A, Derks R, Janse JJ, Mouwenda YD, Kremsner PG, Adegnika AA, Lell B, Everts B, Mayboroda OA, Yazdanbakhsh M. Betouke Ongwe ME, et al. Among authors: janse jj. Metabolites. 2022 Dec 6;12(12):1224. doi: 10.3390/metabo12121224. Metabolites. 2022. PMID: 36557262 Free PMC article.
Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.
Houlder EL, Costain AH, Nambuya I, Brown SL, Koopman JPR, Langenberg MCC, Janse JJ, Hoogerwerf MA, Ridley AJL, Forde-Thomas JE, Colombo SAP, Winkel BMF, Galdon AA, Hoffmann KF, Cook PC, Roestenberg M, Mpairwe H, MacDonald AS. Houlder EL, et al. Among authors: janse jj. Nat Commun. 2023 Apr 3;14(1):1863. doi: 10.1038/s41467-023-37502-z. Nat Commun. 2023. PMID: 37012228 Free PMC article.
Safety and Immunogenicity of Intradermal Fractional Dose Administration of the mRNA-1273 Vaccine: A Proof-of-Concept Study.
Roozen GVT, Prins MLM, van Binnendijk R, den Hartog G, Kuiper VP, Prins C, Janse JJ, Kruithof AC, Feltkamp MCW, Kuijer M, Rosendaal FR, Roestenberg M, Visser LG, Roukens AHE. Roozen GVT, et al. Among authors: janse jj. Ann Intern Med. 2022 Dec;175(12):1771-1774. doi: 10.7326/M22-2089. Epub 2022 Oct 25. Ann Intern Med. 2022. PMID: 36279543 Free PMC article. No abstract available.
Immune responses to SARS-CoV-2 in sub-Saharan Africa and western Europe: a retrospective, population-based, cross-sectional study.
Mbow M, Hoving D, Cisse M, Diallo I, Honkpehedji YJ, Huisman W, Pothast CR, Jongsma MLM, König MH, de Kroon AC, Linh LTK, Azimi S, Tak T, Kruize YCM, Kurniawan F, Dia YA, Zhang JLH, Prins C, Roukens AHE, de Vries JJC, Wammes LJ, Smits HH, Adegnika AA, Zlei M, Kuijpers TW, Wieske L, Dieye A, Mboup S, Kremsner PG, Eftimov F, Velavan TP, Berlin I, Heemskerk MHM, Yazdanbakhsh M, Jochems SP; BEAT-COVID consortium; COVID-19 Leiden University Medical Center study team. Mbow M, et al. Lancet Microbe. 2025 Feb;6(2):100942. doi: 10.1016/j.lanmic.2024.07.005. Epub 2024 Dec 18. Lancet Microbe. 2025. PMID: 39708825 Free article.
32 results