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Review
. 2021 Jul;68(4):1886-1894.
doi: 10.1111/tbed.13909. Epub 2020 Nov 26.

Bovine kobuvirus-A comprehensive review

Lili Hao  1 , Chaoxi Chen  1 , Keith Bailey  2 , Leyi Wang  2
Affiliations
Review

Bovine kobuvirus-A comprehensive review

Lili Hao et al. Transbound Emerg Dis. 2021 Jul.

Abstract

Bovine kobuvirus (BKV) is a single-stranded, positive sense, non-enveloped RNA virus in genus Kobuvirus of family Picornavirus. BKV was first identified in the culture media of HeLa cell containing calf serum in 2003. Since then, BKV has been detected in 13 countries of four different continents, suggesting widespread in the world. Herein, we review the detection and genomic characterization of BKV in 13 countries. All studies tested bovine faecal samples for BKV. These studies provide evidence that BKV might be a causative agent for neonatal calf diarrhoea. Therefore, further efforts including animal challenge study are urgently needed to unveil the pathogenicity of BKV.

Keywords: RT-PCR; bovine kobuvirus; detection; genomic sequence; rRT-PCR.

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References

REFERENCES

    1. Barry, A. F., Ribeiro, J., Alfieri, A. F., van der Poel, W. H., & Alfieri, A. A. (2011). First detection of kobuvirus in farm animals in Brazil and the Netherlands. Infection, Genetics and Evolution, 11(7), 1811-1814. https://doi.org/10.1016/j.meegid.2011.06.020
    1. Candido, M., Batinga, M. C. A., Alencar, A. L. F., de Almeida-Queiroz, S. R., da Glória Buzinaro, M., Livonesi, M. C., Fernandes, A. M., & de Sousa, R. L. M. (2017). Molecular characterization and genetic diversity of bovine Kobuvirus, Brazil. Virus Genes, 53(1), 105-110. https://doi.org/10.1007/s11262-016-1391-1
    1. Chang, J., Wang, Q., Wang, F., Jiang, Z., Liu, Y., & Yu, L. (2014). Prevalence and genetic diversity of bovine kobuvirus in China. Archives of Virology, 159(6), 1505-1510. https://doi.org/10.1007/s00705-013-1961-7
    1. Di Martino, B., Di Profio, F., Di Felice, E., Ceci, C., Pistilli, M. G., & Marsilio, F. (2012). Molecular detection of bovine kobuviruses in Italy. Archives of Virology, 157(12), 2393-2396. https://doi.org/10.1007/s00705-012-1439-z
    1. Isidan, H., Turan, T., Atasoy, M. O., Sozdutmaz, I., & Irehan, B. (2019). Detection and first molecular characterisation of three picornaviruses from diarrhoeic calves in Turkey. Acta Veterinaria Hungarica, 67(3), 463-476. https://doi.org/10.1556/004.2019.046

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