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Randomized Phase Ib Clinical Trial of DB-020 Intratympanic Injections to Reduce High-Dose Cisplatin Ototoxicity.
Panizza BJ, O'Leary SJ, Hart CD, Diwakarla CS, Barnett C, Lapuerta P, Lee J, Raines S, Quigley T, Wolff HM, Keilty J, Ladwa R, Porceddu SV, McGrath M, Seetharamu N, Fua T, Rischin D. Panizza BJ, et al. Among authors: keilty j. J Clin Oncol. 2025 Jul;43(19):2155-2163. doi: 10.1200/JCO.24.00905. Epub 2025 May 22. J Clin Oncol. 2025. PMID: 40403227 Free PMC article. Clinical Trial.
Population-scale analysis of common and rare genetic variation associated with hearing loss in adults.
Praveen K, Dobbyn L, Gurski L, Ayer AH, Staples J, Mishra S, Bai Y, Kaufman A, Moscati A, Benner C, Chen E, Chen S, Popov A, Smith J; GHS-REGN DiscovEHR collaboration; Regeneron Genetics Center; Decibel-REGN collaboration; Melander O, Jones MB, Marchini J, Balasubramanian S, Zambrowicz B, Drummond MC, Baras A, Abecasis GR, Ferreira MA, Stahl EA, Coppola G. Praveen K, et al. Commun Biol. 2022 Jun 3;5(1):540. doi: 10.1038/s42003-022-03408-7. Commun Biol. 2022. PMID: 35661827 Free PMC article.
The mahogany protein is a receptor involved in suppression of obesity.
Nagle DL, McGrail SH, Vitale J, Woolf EA, Dussault BJ Jr, DiRocco L, Holmgren L, Montagno J, Bork P, Huszar D, Fairchild-Huntress V, Ge P, Keilty J, Ebeling C, Baldini L, Gilchrist J, Burn P, Carlson GA, Moore KJ. Nagle DL, et al. Among authors: keilty j. Nature. 1999 Mar 11;398(6723):148-52. doi: 10.1038/18210. Nature. 1999. PMID: 10086355
Phase 1 study to evaluate safety, tolerability and pharmacokinetics of a novel intra-tympanic administered thiosulfate to prevent cisplatin-induced hearing loss in cancer patients.
Viglietta V, Shi F, Hu QY, Ren Y, Keilty J, Wolff H, McCarthy R, Kropp J, Weber P, Soglia J. Viglietta V, et al. Among authors: keilty j. Invest New Drugs. 2020 Oct;38(5):1463-1471. doi: 10.1007/s10637-020-00918-1. Epub 2020 Mar 10. Invest New Drugs. 2020. PMID: 32157599 Free PMC article. Clinical Trial.