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Page 1
Showing results for kinase s
Search for Kinane S instead (1 results)
FDA-approved small-molecule kinase inhibitors.
Wu P, Nielsen TE, Clausen MH. Wu P, et al. Trends Pharmacol Sci. 2015 Jul;36(7):422-39. doi: 10.1016/j.tips.2015.04.005. Epub 2015 May 12. Trends Pharmacol Sci. 2015. PMID: 25975227 Review.
Kinases have emerged as one of the most intensively pursued targets in current pharmacological research, especially for cancer, due to their critical roles in cellular signaling. ...Here we present all approved small-molecule kinase inhibitors with an emphasis on bi …
Kinases have emerged as one of the most intensively pursued targets in current pharmacological research, especially for cancer, due t …
The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling.
Stegmann M, Monaghan J, Smakowska-Luzan E, Rovenich H, Lehner A, Holton N, Belkhadir Y, Zipfel C. Stegmann M, et al. Science. 2017 Jan 20;355(6322):287-289. doi: 10.1126/science.aal2541. Science. 2017. PMID: 28104890 Free article.
This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID …
This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced comple …
High-sensitivity measurements of multiple kinase activities in live single cells.
Regot S, Hughey JJ, Bajar BT, Carrasco S, Covert MW. Regot S, et al. Cell. 2014 Jun 19;157(7):1724-34. doi: 10.1016/j.cell.2014.04.039. Cell. 2014. PMID: 24949979 Free PMC article.
Our reporters reproduce kinase activity for multiple types of kinases and allow for calculation of active kinase concentrations via a mathematical model. ...Our approach opens the possibility of analyzing a wide range of kinase-mediated processes in in …
Our reporters reproduce kinase activity for multiple types of kinases and allow for calculation of active kinase concen …
Small-Molecule Kinase Downregulators.
Jones LH. Jones LH. Cell Chem Biol. 2018 Jan 18;25(1):30-35. doi: 10.1016/j.chembiol.2017.10.011. Epub 2017 Nov 22. Cell Chem Biol. 2018. PMID: 29174540 Free article. Review.
New opportunities to advance small-molecule kinase ligands that downregulate their cognate target binding proteins are discussed. Rationally designed heterobifunctional kinase degraders are compared with ATP site ligands that were serendipitously found to cause k …
New opportunities to advance small-molecule kinase ligands that downregulate their cognate target binding proteins are discussed. Rat …
Allosteric regulation of kinase activity.
Andreotti AH, Dötsch V. Andreotti AH, et al. Elife. 2024 Jul 10;13:e97084. doi: 10.7554/eLife.97084. Elife. 2024. PMID: 38984616 Free PMC article.
The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation....
The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper …
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.
Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R; Cancer Genome Project. Wan PT, et al. Cell. 2004 Mar 19;116(6):855-67. doi: 10.1016/s0092-8674(04)00215-6. Cell. 2004. PMID: 15035987 Free article.
Over 30 mutations of the B-RAF gene associated with human cancers have been identified, the majority of which are located within the kinase domain. Here we show that of 22 B-RAF mutants analyzed, 18 have elevated kinase activity and signal to ERK in vivo. Surprising …
Over 30 mutations of the B-RAF gene associated with human cancers have been identified, the majority of which are located within the kina …
Conformation-tunable ATP-competitive kinase inhibitors.
Agius MP, Ko K, Johnson TK, Phadke S, Soellner MB. Agius MP, et al. Chem Commun (Camb). 2022 Mar 10;58(21):3541-3544. doi: 10.1039/d1cc06893h. Chem Commun (Camb). 2022. PMID: 35195624
We profiled each pair of kinase inhibitors across 468 kinases and identified 38 kinases that could be studied using these pair of conformation-selective inhibitors. We also explore the binding of conformation-selective kinase inhibitors to mutant ki …
We profiled each pair of kinase inhibitors across 468 kinases and identified 38 kinases that could be studied using the …
NAD+ kinase--a review.
McGuinness ET, Butler JR. McGuinness ET, et al. Int J Biochem. 1985;17(1):1-11. doi: 10.1016/0020-711x(85)90079-5. Int J Biochem. 1985. PMID: 2987053 Review.
NAD+ kinase catalyzes the only (known) biochemical reaction leading to the production of NADP+ from NAD+. ...Is calmodulin an integral subunit of (some, all) NAD+ kinases (analogous to phosphorylase kinase in skeletal muscle)? Or is it an external modulator? …
NAD+ kinase catalyzes the only (known) biochemical reaction leading to the production of NADP+ from NAD+. ...Is calmodulin an integra …
Kinase signaling pathways as potential targets in the treatment of Parkinson's disease.
Greggio E, Singleton A. Greggio E, et al. Expert Rev Proteomics. 2007 Dec;4(6):783-92. doi: 10.1586/14789450.4.6.783. Expert Rev Proteomics. 2007. PMID: 18067416 Review.
Mutations of five genes have been unequivocally linked to PD; two of these, LRRK2 and PINK1, encode kinases and as such are attractive tools with which to understand the disease process; furthermore, preliminary functional data suggests that these proteins, or the pathways …
Mutations of five genes have been unequivocally linked to PD; two of these, LRRK2 and PINK1, encode kinases and as such are attractiv …
Development of Kinase-Centric Drugs: A Computational Perspective.
Pratap Reddy Gajulapalli V. Pratap Reddy Gajulapalli V. ChemMedChem. 2023 Oct 4;18(19):e202200693. doi: 10.1002/cmdc.202200693. Epub 2023 Sep 4. ChemMedChem. 2023. PMID: 37442809 Review.
Because members of the same family have similar sequences and structural patterns, often complex relationships between kinases and inhibitors are observed. To design and develop drugs with desired selectivity, it is essential to understand the target selectivity for kin …
Because members of the same family have similar sequences and structural patterns, often complex relationships between kinases and in …
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