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Page 1
Reprogramming of fatty acid metabolism in cancer.
Koundouros N, Poulogiannis G. Koundouros N, et al. Br J Cancer. 2020 Jan;122(1):4-22. doi: 10.1038/s41416-019-0650-z. Epub 2019 Dec 10. Br J Cancer. 2020. PMID: 31819192 Free PMC article. Review.
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.
Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E; CRUK Rosetta Grand Challenge Consortium; Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ. Najumudeen AK, et al. Nat Genet. 2021 Jan;53(1):16-26. doi: 10.1038/s41588-020-00753-3. Epub 2021 Jan 7. Nat Genet. 2021. PMID: 33414552
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase.
Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Ferrarone JR, et al. Among authors: koundouros n. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121. doi: 10.1073/pnas.2403685121. Epub 2024 May 14. Proc Natl Acad Sci U S A. 2024. PMID: 38743625 Free PMC article.
Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition.
Nagiec MJ, Cavaliere PM, Dundar F, Spencer DM, Koundouros N, Nunes JB, Shin S, Yoon SO, Han J, Chavez A, Kester OM, Khan R, Zumbo P, Gardner EE, Parang B, Mutvei AP, Asara JM, Gygi SP, Betel D, Dephoure N, Blenis J. Nagiec MJ, et al. Among authors: koundouros n. bioRxiv [Preprint]. 2025 Sep 23:2025.09.22.677807. doi: 10.1101/2025.09.22.677807. bioRxiv. 2025. PMID: 41040296 Free PMC article. Preprint.
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry NJS, Magee DJ, Anjomani Virmouni S, Elder GA, Tyson AL, Dória ML, van Weverwijk A, Soares RF, Isacke CM, Nicholson JK, Glen RC, Takats Z, Poulogiannis G. Koundouros N, et al. Cell. 2020 Jun 25;181(7):1596-1611.e27. doi: 10.1016/j.cell.2020.05.053. Epub 2020 Jun 18. Cell. 2020. PMID: 32559461 Free PMC article.
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