Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Jun 25;1173(3):325-8.
doi: 10.1016/0167-4781(93)90131-v.

Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes

F K Lin  1 , C H Lin, C C Chou, K Chen, H S Lu, W Bacheller, C Herrera, T Jones, J Chao, L Chao
Affiliations

Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes

F K Lin et al. Biochim Biophys Acta. .

Abstract

Cynomolgus monkey renal kallikrein cDNA and genomic human tissue kallikrein gene were cloned. The monkey gene encodes a 257 amino acid (aa) preprokallikrein and exhibits 95% and 92% homology to the human at nucleotide (nt) and aa level, respectively. The monkey gene encodes a 233-aa mature kallikrein versus a 238-aa in human. The human kallikrein gene and urinary kallikrein both contain a Lys-162 instead of the reported Glu-162. Human, monkey and rat renal/pancreatic kallikrein genes evolve with a N-glycosylation containing domain (aa 81-87) which is absent in porcine and is non-glycosylable in mice. Only human kallikrein evolves with an additional Thr-108 and with a N-glycosylation site at aa-141.

PubMed Disclaimer

Publication types

LinkOut - more resources