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. 1995 May 23;92(11):4997-5000.
doi: 10.1073/pnas.92.11.4997.

Evidence for cross-pathway regulation of metabolic gene expression in plants

D Guyer  1 , D Patton, E Ward
Affiliations

Evidence for cross-pathway regulation of metabolic gene expression in plants

D Guyer et al. Proc Natl Acad Sci U S A. .

Abstract

In Arabidopsis thaliana, blocking histidine biosynthesis with a specific inhibitor of imidazoleglycerol-phosphate dehydratase caused increased expression of eight genes involved in the biosynthesis of aromatic amino acids, histidine, lysine, and purines. A decrease in expression of glutamine synthetase was also observed. Addition of histidine eliminated the gene-regulating effects of the inhibitor, demonstrating that the changes in gene expression resulted from histidine-pathway blockage. These results show that plants are capable of cross-pathway metabolic regulation.

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