Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant.
Biochem J. 1997 Jan 1;321 ( Pt 1)(Pt 1):165-75. doi: 10.1042/bj3210165.
Biochem J. 1997.
PMID: 9003416
Free PMC article.