Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;67(2):994-1007.
doi: 10.1111/tbed.13434. Epub 2019 Dec 16.

Co-circulation and characterization of HPAI-H5N1 and LPAI-H9N2 recovered from a duck farm, Yogyakarta, Indonesia

Lestari  1   2 , Hendra Wibawa  2 , Elly Puspasari Lubis  2 , Rama Dharmawan  2 , Rina Astuti Rahayu  2 , Herdiyanto Mulyawan  2 , Kamonpan Charoenkul  1 , Chanakarn Nasamran  1 , Bagoes Poermadjaja  2 , Alongkorn Amonsin  1
Affiliations

Co-circulation and characterization of HPAI-H5N1 and LPAI-H9N2 recovered from a duck farm, Yogyakarta, Indonesia

Lestari et al. Transbound Emerg Dis. 2020 Mar.

Abstract

In July 2016, an avian influenza outbreak in duck farms in Yogyakarta province was reported to Disease Investigation Center (DIC), Wates, Indonesia, with approximately 1,000 ducks died or culled. In this study, two avian influenza (AI) virus subtypes, A/duck/Bantul/04161291-OR/2016 (H5N1) and A/duck/Bantul/04161291-OP/2016 (H9N2) isolated from ducks in the same farm during an AI outbreak in Bantul district, Yogyakarta province, were sequenced and characterized. Our results showed that H5N1 virus was closely related to the highly pathogenic AI (HPAI) H5N1 of clade 2.3.2.1c, while the H9N2 virus was clustered with LPAI viruses from China, Vietnam and Indonesia H9N2 (CVI lineage). Genetic analysis revealed virulence characteristics for both in avian and in mammalian species. In summary, co-circulation of HPAI-H5N1 of clade 2.3.2.1c and LPAI-H9N2 was identified in a duck farm during an AI outbreak in Yogyakarta province, Indonesia. Our findings raise a concern of the potential risk of the viruses, which could increase viral transmission and/or threat to human health. Routine surveillance of avian influenza viruses should be continuously conducted to understand the dynamic and diversity of the viruses for influenza prevention and control in Indonesia and SEA region.

Keywords: H5N1; H9N2; Indonesia; Influenza; co-circulation.

PubMed Disclaimer

References

REFERENCES

    1. Aamir, U. B., Wernery, U., Ilyushina, N., & Webster, R. G. (2007). Characterization of avian H9N2 influenza viruses from United Arab Emirates 2000 to 2003. Journal of Virology, 361(1), 45-55. https://doi.org/10.1016/j.virol.2006.10.037
    1. Butt, K. M., Smith, G. J. D., Chen, H., Zhang, L. J., Leung, Y. H. C., Xu, K. M., … Guan, Y. (2005). Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003. Journal of Clinical Microbiology, 43(11), 5760-5767. https://doi.org/10.1128/JCM.43.11.5760-5767.2005
    1. Chen, H., Yuan, H., Gao, R., Zhang, J., Wang, D., Xiong, Y., … Zhou, J. (2014). Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: A descriptive study. Lancet (London, England), 383(9918), 714-721.
    1. Claas, E. C., Osterhaus, A. D., Van Beek, R., De Jong, J. C., Rimmelzwaan, G. F., Senne, D. A., … Webster, R. G. (1998). Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet (London, England), 351(9101), 472-477.
    1. Conenello, G. M., Zamarin, D., Perrone, L. A., Tumpey, T., & Palese, P. (2007). A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence. PLoS Pathogens, 3(10), e141. https://doi.org/10.1371/journal.ppat.0030141

MeSH terms

Associated data

LinkOut - more resources