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Page 1
Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects.
Konecny J, Misiachna A, Chvojkova M, Kleteckova L, Kolcheva M, Novak M, Prchal L, Ladislav M, Hemelikova K, Netolicky J, Hrabinova M, Kobrlova T, Karasova JZ, Pejchal J, Fibigar J, Vecera Z, Kucera T, Jendelova P, Zahumenska P, Langore E, Doderovic J, Pang YP, Vales K, Korabecny J, Soukup O, Horak M. Konecny J, et al. Among authors: ladislav m. Eur J Med Chem. 2024 Dec 15;280:116981. doi: 10.1016/j.ejmech.2024.116981. Epub 2024 Oct 18. Eur J Med Chem. 2024. PMID: 39442339 Free article.
Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition.
Misiachna A, Konecny J, Kolcheva M, Ladislav M, Prchal L, Netolicky J, Kortus S, Zahumenska P, Langore E, Novak M, Hemelikova K, Hermanova Z, Hrochova M, Pelikanova A, Odvarkova J, Pejchal J, Kassa J, Zdarova Karasova J, Korabecny J, Soukup O, Horak M. Misiachna A, et al. Among authors: ladislav m. Biomed Pharmacother. 2024 Sep;178:117201. doi: 10.1016/j.biopha.2024.117201. Epub 2024 Jul 24. Biomed Pharmacother. 2024. PMID: 39053419 Free article.
Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity.
Hubalkova P, Ladislav M, Vyklicky V, Smejkalova T, Hrcka Krausova B, Kysilov B, Krusek J, Naimová Z, Korinek M, Chodounska H, Kudova E, Cerny J, Vyklicky L Jr. Hubalkova P, et al. Among authors: ladislav m. J Neurosci. 2021 Mar 10;41(10):2119-2134. doi: 10.1523/JNEUROSCI.2654-20.2021. Epub 2021 Feb 1. J Neurosci. 2021. PMID: 33526476 Free PMC article.
Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits.
Netolicky J, Zahumenska P, Misiachna A, Kolcheva M, Rehakova K, Hemelikova K, Kortus S, Langore E, Doderovic J, Ladislav M, Korabecny J, Otyepka M, Srejber M, Horak M. Netolicky J, et al. Among authors: ladislav m. J Neurosci. 2025 Jun 25;45(26):e0226242025. doi: 10.1523/JNEUROSCI.0226-24.2025. J Neurosci. 2025. PMID: 40425318 Free PMC article.
Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment.
Svobodova B, Moravcova Z, Misiachna A, Novakova G, Marek A, Finger V, Odvarkova J, Pejchal J, Karasova JZ, Netolicky J, Ladislav M, Hrabinova M, Sorf A, Muckova L, Fikejzlova L, Benkova M, Novak M, Prchal L, Capek J, Handl J, Rousar T, Greber KE, Ciura K, Horak M, Soukup O, Korabecny J. Svobodova B, et al. Among authors: ladislav m. Eur J Med Chem. 2025 Aug 5;292:117678. doi: 10.1016/j.ejmech.2025.117678. Epub 2025 Apr 22. Eur J Med Chem. 2025. PMID: 40288120 Free article.
Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes.
Kortus S, Rehakova K, Klima M, Kolcheva M, Ladislav M, Langore E, Barackova P, Netolicky J, Misiachna A, Hemelikova K, Humpolickova J, Chalupska D, Silhan J, Kaniakova M, Hrcka Krausova B, Boura E, Zapotocky M, Horak M. Kortus S, et al. Among authors: ladislav m. J Neurosci. 2023 Jun 28;43(26):4755-4774. doi: 10.1523/JNEUROSCI.2014-22.2023. Epub 2023 Jun 7. J Neurosci. 2023. PMID: 37286354 Free PMC article.
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.
Kolcheva M, Ladislav M, Netolicky J, Kortus S, Rehakova K, Krausova BH, Hemelikova K, Misiachna A, Kadkova A, Klima M, Chalupska D, Horak M. Kolcheva M, et al. Among authors: ladislav m. Neuropharmacology. 2023 Jan 1;222:109297. doi: 10.1016/j.neuropharm.2022.109297. Epub 2022 Nov 1. Neuropharmacology. 2023. PMID: 36341805 Free article.
18 results