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A lysosomal surveillance response to stress extends healthspan.
Li TY, Gao AW, Yang R, Sun Y, Lei Y, Li X, Chen L, Liu YJ, Arey RN, Morales K, Liu RB, Wang W, Zhou A, Zhao TJ, Li W, Lalou A, Wang Q, Lima T, Houtkooper RH, Auwerx J. Li TY, et al. Among authors: lalou a. Nat Cell Biol. 2025 Jul;27(7):1083-1097. doi: 10.1038/s41556-025-01693-y. Epub 2025 Jun 26. Nat Cell Biol. 2025. PMID: 40571723 Free PMC article.
High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.
Gao AW, El Alam G, Zhu Y, Li W, Sulc J, Li X, Katsyuba E, Li TY, Overmyer KA, Lalou A, Mouchiroud L, Sleiman MB, Cornaglia M, Morel JD, Houtkooper RH, Coon JJ, Auwerx J. Gao AW, et al. Among authors: lalou a. Cell Rep. 2024 Oct 22;43(10):114836. doi: 10.1016/j.celrep.2024.114836. Epub 2024 Oct 4. Cell Rep. 2024. PMID: 39368088 Free PMC article.
Mathematical Modelling in Hydrocephalus.
Kazimierska A, Ziółkowski A, Kasprowicz M, Lalou A, Czosnyka Z, Czosnyka M. Kazimierska A, et al. Among authors: lalou a. Neurol India. 2021 Nov-Dec;69(Supplement):S275-S282. doi: 10.4103/0028-3886.332259. Neurol India. 2021. PMID: 35102977 Free article. Review.
Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.
Wohlwend M, Laurila PP, Goeminne LJE, Lima T, Daskalaki I, Li X, von Alvensleben G, Crisol B, Mangione R, Gallart-Ayala H, Lalou A, Burri O, Butler S, Morris J, Turner N, Ivanisevic J, Auwerx J. Wohlwend M, et al. Among authors: lalou a. Elife. 2024 Mar 20;12:RP90522. doi: 10.7554/eLife.90522. Elife. 2024. PMID: 38506902 Free PMC article.
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging.
Civiletto G, Brunetti D, Lizzo G, Muller K, Jacot GE, Daskalaki I, Sizzano F, Huh M, Di Meo I, Colombo MN, Sanchez-Garcia JL, Bétrisey BJ, Zollinger A, Lino P, Neal C, Egesipe AL, Richard J, Chimen M, Hermant A, Brinon B, Texari L, Metairon S, Qureshi MA, Patel DS, Vanapalli SA, Malavolta M, Gao AW, Lalou A, Provinciali M, Orlando F, Tiranti V, Brooke RT, Horvath S, Auwerx J, Feige JN, Gut P. Civiletto G, et al. Among authors: lalou a. Nat Aging. 2025 Sep 24. doi: 10.1038/s43587-025-00957-4. Online ahead of print. Nat Aging. 2025. PMID: 40993327
37 results