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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1815 1
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1948 52
1949 35
1950 120
1951 142
1952 174
1953 244
1954 187
1955 204
1956 127
1957 152
1958 114
1959 130
1960 77
1961 70
1962 69
1963 102
1964 154
1965 113
1966 154
1967 145
1968 249
1969 249
1970 153
1971 179
1972 122
1973 247
1974 325
1975 266
1976 244
1977 240
1978 178
1979 156
1980 176
1981 225
1982 184
1983 218
1984 190
1985 196
1986 185
1987 210
1988 229
1989 199
1990 176
1991 119
1992 79
1993 163
1994 152
1995 124
1996 142
1997 131
1998 164
1999 190
2000 242
2001 274
2002 250
2003 265
2004 270
2005 337
2006 297
2007 357
2008 310
2009 323
2010 381
2011 363
2012 339
2013 390
2014 352
2015 404
2016 430
2017 365
2018 395
2019 398
2020 499
2021 513
2022 493
2023 472
2024 498
2025 457
2026 1

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17,739 results

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Page 1
LAT encodes T cell activation pathway balance.
Rubin AJ, Dao TT, Schueppert AV, Regev A, Shalek AK. Rubin AJ, et al. bioRxiv [Preprint]. 2024 Aug 26:2024.08.26.609683. doi: 10.1101/2024.08.26.609683. bioRxiv. 2024. PMID: 39253472 Free PMC article. Preprint.
Here, we studied how balanced downstream pathway activation is encoded in the amino acid sequence of LAT. To comprehensively profile the sequence-function relationship of LAT, we developed a pooled, single-cell, high-content screening approach in which a large serie …
Here, we studied how balanced downstream pathway activation is encoded in the amino acid sequence of LAT. To comprehensively profile …
The LAT story: a tale of cooperativity, coordination, and choreography.
Balagopalan L, Coussens NP, Sherman E, Samelson LE, Sommers CL. Balagopalan L, et al. Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a005512. doi: 10.1101/cshperspect.a005512. Epub 2010 Jul 7. Cold Spring Harb Perspect Biol. 2010. PMID: 20610546 Free PMC article. Review.
Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. ...Finally, this review explores the function of …
Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, …
Identification of GC-rich LAT genes in birds.
Janusova S, Krchlikova V, Hron T, Elleder D, Stepanek O. Janusova S, et al. PLoS One. 2023 Apr 6;18(4):e0283431. doi: 10.1371/journal.pone.0283431. eCollection 2023. PLoS One. 2023. PMID: 37023062 Free PMC article.
Linker for activation of T cells (LAT) plays a key role in T-cell antigenic signaling in mammals. Accordingly, LAT orthologues were identified in the majority of vertebrates. However, LAT orthologues were not identified in most birds. In this study, we show t …
Linker for activation of T cells (LAT) plays a key role in T-cell antigenic signaling in mammals. Accordingly, LAT orthologues …
Discrete LAT condensates encode antigen information from single pMHC:TCR binding events.
McAffee DB, O'Dair MK, Lin JJ, Low-Nam ST, Wilhelm KB, Kim S, Morita S, Groves JT. McAffee DB, et al. Nat Commun. 2022 Dec 2;13(1):7446. doi: 10.1038/s41467-022-35093-9. Nat Commun. 2022. PMID: 36460640 Free PMC article.
Only the probability of the LAT condensate forming is related to the pMHC:TCR binding dwell time. LAT condenses abruptly, but after an extended delay from the originating binding event. A LAT mutation that facilitates phosphorylation at the PLC-gamma1 recruit …
Only the probability of the LAT condensate forming is related to the pMHC:TCR binding dwell time. LAT condenses abruptly, but …
LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways.
Wange RL. Wange RL. Sci STKE. 2000 Dec 19;2000(63):re1. doi: 10.1126/stke.2000.63.re1. Sci STKE. 2000. PMID: 11752630 Review.
A likely candidate for linking the proximal and distal portions of the TCR signaling pathway is the recently described protein, LAT. LAT is a 36-kD transmembrane protein that becomes rapidly tyrosine-phosphorylated after TCR engagement. ...Notably, in the absence of …
A likely candidate for linking the proximal and distal portions of the TCR signaling pathway is the recently described protein, LAT. …
The transmembrane adapter LAT plays a central role in immune receptor signalling.
Wonerow P, Watson SP. Wonerow P, et al. Oncogene. 2001 Oct 1;20(44):6273-83. doi: 10.1038/sj.onc.1204770. Oncogene. 2001. PMID: 11607829 Review.
The transmembrane adapter LAT (linker for activation of T cells) plays a central role in signalling by ITAM bearing receptors expressed on T cells, natural killer cells, mast cells and platelets. ...The study of LAT-deficient mice and LAT-deficient cell lines …
The transmembrane adapter LAT (linker for activation of T cells) plays a central role in signalling by ITAM bearing receptors express …
Identification of LAT/ZAP70 characterized immune subtypes of prostate cancer.
Yu J, Gao W, Gao S, Wen S, Zhao Y, Shang Z, Wang Y, Niu Y. Yu J, et al. World J Urol. 2022 Nov;40(11):2817-2824. doi: 10.1007/s00345-022-04170-5. Epub 2022 Oct 7. World J Urol. 2022. PMID: 36205741
However, PCa genomic and clinical data regarding the role of LAT and ZAP70 are limited. We aim to identify and characterize LAT/ZAP70 defined subtypes of PCa. ...LAT/ZAP70-associated immune infiltration was evaluated using bioinformatic tools. Immunohistochem …
However, PCa genomic and clinical data regarding the role of LAT and ZAP70 are limited. We aim to identify and characterize LAT …
IFNbeta absence compensates for LAT functions in latency reactivation and T cell exhaustion.
Wang S, Jaggi U, Oh JJ, Ghiasi H. Wang S, et al. J Virol. 2025 Jun 17;99(6):e0037425. doi: 10.1128/jvi.00374-25. Epub 2025 May 12. J Virol. 2025. PMID: 40353667 Free PMC article.
Since the role of IFNbeta in HSV-1 latency reactivation and the potential effect of latency-associated transcript (LAT) on IFNbeta activity is not known, we ocularly infected IFNbeta(-/-) mice with different doses of LAT-plus [LAT(+)] and LAT-minus [ …
Since the role of IFNbeta in HSV-1 latency reactivation and the potential effect of latency-associated transcript (LAT) on IFNbeta ac …
HSV LAT and neuronal survival.
Bloom DC. Bloom DC. Int Rev Immunol. 2004 Jan-Apr;23(1-2):187-98. doi: 10.1080/08830180490265592. Int Rev Immunol. 2004. PMID: 14690860 Review.
While mutational analyses indicate LAT is nonessential for viral replication, the 5' exon of LAT greatly enhances reactivation. Several studies have also identified LAT mutations that reduce establishment of latency and enhance virulence. Recently, LAT …
While mutational analyses indicate LAT is nonessential for viral replication, the 5' exon of LAT greatly enhances reactivation …
Role of the LAT adaptor in T-cell development and Th2 differentiation.
Malissen B, Aguado E, Malissen M. Malissen B, et al. Adv Immunol. 2005;87:1-25. doi: 10.1016/S0065-2776(05)87001-4. Adv Immunol. 2005. PMID: 16102570 Review.
This unexpected finding revealed that LAT also constitutes a negative regulator of TCR signalling and T-cell homeostasis. Although LAT is also expressed in mast cells, natural killer cells, megakaryocytes, platelets, and early B cells, the present review specificall …
This unexpected finding revealed that LAT also constitutes a negative regulator of TCR signalling and T-cell homeostasis. Although …
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