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Page 1
Genome-wide association study of long COVID.
Lammi V, Nakanishi T, Jones SE, Andrews SJ, Karjalainen J, Cortés B, O'Brien HE, Ochoa-Guzman A, Fulton-Howard BE, Broberg M, Haapaniemi HH, Kanai M, Pirinen M, Schmidt A, Mitchell RE, Mousas A, Mangino M, Huerta-Chagoya A, Sinnott-Armstrong N, Cirulli ET, Vaudel M, Kwong ASF, Maiti AK, Marttila MM, Posner DC, Rodriguez AA, Batini C, Minnai F, Dearman AR, Warmerdam CAR, Sequeros CB, Winkler TW, Jordan DM, Rešcenko R, Miano L, Lane JM, Chung RK, Guillen-Guio B, Leavy OC, Carvajal-Silva L, Aguilar-Valdés K, Frangione E, Guare L, Vergasova E, Marouli E, Striano P, Zainulabid UA, Kumar A, Ahmad HF, Edahiro R, Azekawa S; Long COVID Host Genetics Initiative; FinnGen; VA Million Veteran Program; MexGen-COVID Initiative; DBDS Genomic Consortium; GEN-COVID Multicenter Study; PHOSP-COVID Collaborative Group; GENCOV Study; Estonian Biobank Research Team; Luoh SW, Erikstrup C, Pedersen OBV, Lerner-Ellis J, Colombo A, Grzymski JJ, Ishii M, Okada Y, Beckmann ND, Kumari M, Wagner R, Heid IM, John C, Short PJ, Magnus P, Ansone L, Valenti LVC, Lee SA, Wain LV, Verdugo RA, Banasik K, Geller F, Franke LH, Rakitko A, Duncan EL, Renieri A, Tsilidis KK, de Cid R, Niavarani A, Abner E, Tusié-Luna T, Ver… See abstract for full author list ➔ Lammi V, et al. Nat Genet. 2025 Jun;57(6):1402-1417. doi: 10.1038/s41588-025-02100-w. Epub 2025 May 21. Nat Genet. 2025. PMID: 40399555 Free PMC article.
Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue.
Chen ZJ, Das SS, Kar A, Lee SHT, Abuhanna KD, Alvarez M, Sukhatme MG, Wang Z, Gelev KZ, Heffel MG, Zhang Y, Avram O, Rahmani E, Sankararaman S, Laakso M, Heinonen S, Peltoniemi H, Halperin E, Pietiläinen KH, Luo C, Pajukanta P. Chen ZJ, et al. Among authors: lee sht. Nat Genet. 2025 Sep;57(9):2238-2249. doi: 10.1038/s41588-025-02300-4. Epub 2025 Aug 20. Nat Genet. 2025. PMID: 40835891 Free PMC article.
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease.
Lee SHT, Garske KM, Arasu UT, Kar A, Miao Z, Alvarez M, Koka A, Darci-Maher N, Benhammou JN, Pan DZ, Örd T, Kaminska D, Männistö V, Heinonen S, Wabitsch M, Laakso M, Agopian VG, Pisegna JR, Pietiläinen KH, Pihlajamäki J, Kaikkonen MU, Pajukanta P. Lee SHT, et al. EBioMedicine. 2024 Aug;106:105232. doi: 10.1016/j.ebiom.2024.105232. Epub 2024 Jul 10. EBioMedicine. 2024. PMID: 38991381 Free PMC article.
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease.
Darci-Maher N, Alvarez M, Arasu UT, Selvarajan I, Lee SHT, Pan DZ, Miao Z, Das SS, Kaminska D, Örd T, Benhammou JN, Wabitsch M, Pisegna JR, Männistö V, Pietiläinen KH, Laakso M, Sinsheimer JS, Kaikkonen MU, Pihlajamäki J, Pajukanta P. Darci-Maher N, et al. Among authors: lee sht. EBioMedicine. 2023 Jun;92:104620. doi: 10.1016/j.ebiom.2023.104620. Epub 2023 May 22. EBioMedicine. 2023. PMID: 37224770 Free PMC article.
Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue.
Chen ZJ, Das SS, Kar A, Lee SHT, Abuhanna KD, Alvarez M, Sukhatme MG, Gelev KZ, Heffel MG, Zhang Y, Avram O, Rahmani E, Sankararaman S, Heinonen S, Peltoniemi H, Halperin E, Pietiläinen KH, Luo C, Pajukanta P. Chen ZJ, et al. Among authors: lee sht. bioRxiv [Preprint]. 2024 Nov 3:2024.11.02.621694. doi: 10.1101/2024.11.02.621694. bioRxiv. 2024. Update in: Nat Genet. 2025 Sep;57(9):2238-2249. doi: 10.1038/s41588-025-02300-4. PMID: 39554055 Free PMC article. Updated. Preprint.
Integration of single cell omics with biobank data discovers trans effects of SREBF1 abdominal obesity risk variants on adipocyte expression of more than 100 genes.
Sukhatme MG, Kar A, Arasu UT, Lee SHT, Alvarez M, Garske KM, Gelev KZ, Rajkumar S, Das SS, Kaminska D, Männistö V, Peltoniemi H, Heinonen S, Säiläkivi U, Saarinen T, Juuti A, Pietiläinen KH, Pihlajamäki J, Kaikkonen MU, Pajukanta P. Sukhatme MG, et al. Among authors: lee sht. medRxiv [Preprint]. 2024 Nov 23:2024.11.22.24317804. doi: 10.1101/2024.11.22.24317804. medRxiv. 2024. PMID: 39606332 Free PMC article. Preprint.
Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity.
Heikkinen A, Esser VFC, Lee SHT, Lundgren S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Heinonen S, Villicaña S, Bell JT, Maguolo A, Nilsson E, Ling C, Vaag A, Pajukanta P, Kaprio J, Pietiläinen KH, Li S, Ollikainen M. Heikkinen A, et al. Among authors: lee sht. Nat Commun. 2025 May 12;16(1):4374. doi: 10.1038/s41467-025-59576-7. Nat Commun. 2025. PMID: 40355419 Free PMC article.
An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns.
Deal M, Kar A, Lee SHT, Alvarez M, Rajkumar S, Arasu UT, Kaminska D, Männistö V, Heinonen S, van der Kolk BW, Säiläkivi U, Saarinen T, Juuti A, Pihlajamäki J, Kaikkonen MU, Laakso M, Pietiläinen KH, Pajukanta P. Deal M, et al. Among authors: lee sht. Am J Hum Genet. 2024 Nov 7;111(11):2542-2560. doi: 10.1016/j.ajhg.2024.10.001. Am J Hum Genet. 2024. PMID: 39515300 Free PMC article.
20 results