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Page 1
Showing results for luther ic
Search for Lether IC instead (1 results)
Treatment of idiopathic chylothorax in dogs and cats: A systematic review.
Reeves LA, Anderson KM, Luther JK, Torres BT. Reeves LA, et al. Vet Surg. 2020 Jan;49(1):70-79. doi: 10.1111/vsu.13322. Epub 2019 Sep 11. Vet Surg. 2020. PMID: 31508821
OBJECTIVE: To evaluate the evidence published on the treatment of idiopathic chylothorax (IC) in small animals. STUDY DESIGN: Systematic literature review. SAMPLE POPULATION: Dogs and cats with IC. ...CLINICAL SIGNIFICANCE: The best available evidence regarding the …
OBJECTIVE: To evaluate the evidence published on the treatment of idiopathic chylothorax (IC) in small animals. STUDY DESIGN: Systema …
Pathophysiology and clinical manifestations of immune complex vasculitides.
Sunderkötter C, Golle L, Pillebout E, Michl C. Sunderkötter C, et al. Front Med (Lausanne). 2023 Mar 3;10:1103065. doi: 10.3389/fmed.2023.1103065. eCollection 2023. Front Med (Lausanne). 2023. PMID: 36936215 Free PMC article. Review.
Immune complex (IC) vasculitides present inflammations of vessel walls associated with perivascular deposition of immunoglobulins (Igs), mostly ICs. ...The reasons for increased generation of immunoglobulins or formation of IC and their perivascular deposition in ei …
Immune complex (IC) vasculitides present inflammations of vessel walls associated with perivascular deposition of immunoglobulins (Ig …
Data Standardization for Results Management.
Campbell RM, Dymshitz J, Eastwood BJ, Emkey R, Greenen DP, Heerding JM, Johnson D, Large TH, Littlejohn T, Montrose C, Nutter SE, Sawyer BD, Sigmund SK, Smith M, Weidner JR, Zink RW. Campbell RM, et al. 2012 May 1 [updated 2017 Oct 20]. In: Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Grotegut S, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, Norvil A, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli MA, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. 2012 May 1 [updated 2017 Oct 20]. In: Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Grotegut S, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, Norvil A, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli MA, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. PMID: 22553865 Free Books & Documents. Review.
Raw data collected in screening assays should be appropriately analyzed to derive activity expressed as potency or efficacy values of tested compounds (IC(50) or EC(50) values). In this chapter the authors discuss standardized approaches to processing radioligand binding, …
Raw data collected in screening assays should be appropriately analyzed to derive activity expressed as potency or efficacy values of tested …
Assay Operations for SAR Support.
Beck B, Chen YF, Dere W, Devanarayan V, Eastwood BJ, Farmen MW, Iturria SJ, Iversen PW, Kahl SD, Moore RA, Sawyer BD, Weidner J. Beck B, et al. 2012 May 1 [updated 2017 Nov 20]. In: Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Grotegut S, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, Norvil A, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli MA, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. 2012 May 1 [updated 2017 Nov 20]. In: Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Grotegut S, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, Norvil A, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli MA, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. PMID: 22553866 Free Books & Documents. Review.
Most biological assays measure potency of compounds as an activity coefficient, frequently known as molar concentration of inhibitor at 50% response (IC(50)) or an agonist concentration at 50% biological activity (EC(50)). Since biological response responses are non-linear …
Most biological assays measure potency of compounds as an activity coefficient, frequently known as molar concentration of inhibitor at 50% …
Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors.
Baumann A, Papenkordt N, Robaa D, Szigetvari PD, Vogelmann A, Bracher F, Sippl W, Jung M, Haavik J. Baumann A, et al. ACS Chem Neurosci. 2024 Nov 20;15(22):4143-4155. doi: 10.1021/acschemneuro.4c00346. Epub 2024 Nov 10. ACS Chem Neurosci. 2024. PMID: 39523540 Free PMC article.
We show that panobinostat and structurally related compounds such as TB57, which similarly to panobinostat also contains a cinnamoyl hydroxamate, bind to human AAAHs and inhibit these enzymes with high selectivity within the class (panobinostat inhibition (IC(50)): phenyla …
We show that panobinostat and structurally related compounds such as TB57, which similarly to panobinostat also contains a cinnamoyl hydroxa …
Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity.
Baselious F, Hilscher S, Hagemann S, Tripathee S, Robaa D, Barinka C, Hüttelmaier S, Schutkowski M, Sippl W. Baselious F, et al. Arch Pharm (Weinheim). 2024 Oct;357(10):e2400486. doi: 10.1002/ardp.202400486. Epub 2024 Jul 12. Arch Pharm (Weinheim). 2024. PMID: 38996352
Compound 5a proved to be the most active compound with an IC(50) of 365 nM and was able to selectively inhibit HDAC11. Furthermore, docking of 5a showed a binding mode comparable to FT895 but could not adopt any reasonable poses in other HDAC isoforms. ...
Compound 5a proved to be the most active compound with an IC(50) of 365 nM and was able to selectively inhibit HDAC11. Furthermore, d …
Photon Counting Computed Tomography in Rectal Cancer: Associations Between Iodine Concentration, Histopathology and Treatment Response: A Pilot Study.
Surov A, Diallo-Danebrock R, Radi A, Kröger JR, Niehoff JH, Michael AE, Gerdes B, Elhabash S, Wienke A, Borggrefe J. Surov A, et al. Acad Radiol. 2024 Sep;31(9):3620-3626. doi: 10.1016/j.acra.2024.02.006. Epub 2024 Feb 28. Acad Radiol. 2024. PMID: 38418345 Free article.
Photon counting computed tomography (PCCT) improves the imaging quality and can provide multiparametric spectral image information including iodine concentration (IC). Our purpose was to analyze associations between IC and histopathology in RC and to evaluate the ro …
Photon counting computed tomography (PCCT) improves the imaging quality and can provide multiparametric spectral image information including …
Minimum Significant Ratio – A Statistic to Assess Assay Variability.
Haas JV, Eastwood BJ, Iversen PW, Devanarayan V, Weidner JR. Haas JV, et al. 2013 Nov 1 [updated 2017 Nov 20]. In: Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Grotegut S, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, Norvil A, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli MA, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. 2013 Nov 1 [updated 2017 Nov 20]. In: Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Grotegut S, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, Norvil A, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli MA, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. PMID: 24260775 Free Books & Documents. Review.
Standard potency estimates are expressed as IC(50), EC(50) or simply as AC(50) values derived from concentration-response (CRC) assays designed to measure activation, inhibition or modulation of targets and pathways of pharmacological significance. ...
Standard potency estimates are expressed as IC(50), EC(50) or simply as AC(50) values derived from concentration-response (CRC) assay …
Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.
Kaur R, Sharma P, Gupta GK, Ntie-Kang F, Kumar D. Kaur R, et al. Molecules. 2020 Apr 29;25(9):2070. doi: 10.3390/molecules25092070. Molecules. 2020. PMID: 32365518 Free PMC article. Review.
Here, weattempt to summarize the main results, which focus on the structures of most potent plant-based natural products having anti-HIV activity along with their mechanisms of action and IC(50) values, structure-activity-relationships and important key findings....
Here, weattempt to summarize the main results, which focus on the structures of most potent plant-based natural products having anti-HIV act …
Association of preoperative smoking with the occurrence of postoperative pulmonary complications: A post hoc analysis of an observational study in 29 countries.
Dorland G, Saadat W, van Meenen DMP, Neto AS, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Putensen C, Schmid W, Severgnini P, Wrigge H, de Abreu MG, Schultz MJ, Hemmes SNT; LAS VEGAS-investigators. Dorland G, et al. J Clin Anesth. 2025 Jun;104:111856. doi: 10.1016/j.jclinane.2025.111856. Epub 2025 May 14. J Clin Anesth. 2025. PMID: 40373497 Free article.
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