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Page 1
Showing results for li dali g
Search for Li Veli G instead (2 results)
Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke.
Gao Y, Chen W, Pan Y, Jing J, Wang C, Johnston SC, Amarenco P, Bath PM, Jiang L, Yang Y, Wang T, Han S, Meng X, Lin J, Zhao X, Liu L, Zhao J, Li Y, Zang Y, Zhang S, Yang H, Yang J, Wang Y, Li D, Wang Y, Liu D, Kang G, Wang Y, Wang Y; INSPIRES Investigators. Gao Y, et al. Among authors: li d. N Engl J Med. 2023 Dec 28;389(26):2413-2424. doi: 10.1056/NEJMoa2309137. N Engl J Med. 2023. PMID: 38157499 Clinical Trial.
Engineering a precise adenine base editor with minimal bystander editing.
Chen L, Zhang S, Xue N, Hong M, Zhang X, Zhang D, Yang J, Bai S, Huang Y, Meng H, Wu H, Luan C, Zhu B, Ru G, Gao H, Zhong L, Liu M, Liu M, Cheng Y, Yi C, Wang L, Zhao Y, Song G, Li D. Chen L, et al. Among authors: li d. Nat Chem Biol. 2023 Jan;19(1):101-110. doi: 10.1038/s41589-022-01163-8. Epub 2022 Oct 13. Nat Chem Biol. 2023. PMID: 36229683
Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their bystander mutations and off-target editing effects raise safety concerns. ...Importantly, ABE9 induced very minimal RNA and undetectable Cas9-independent DNA off-target effects, w …
Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their bystander mutations and off-target edit …
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing.
Chen L, Zhu B, Ru G, Meng H, Yan Y, Hong M, Zhang D, Luan C, Zhang S, Wu H, Gao H, Bai S, Li C, Ding R, Xue N, Lei Z, Chen Y, Guan Y, Siwko S, Cheng Y, Song G, Wang L, Yi C, Liu M, Li D. Chen L, et al. Among authors: li d. Nat Biotechnol. 2023 May;41(5):663-672. doi: 10.1038/s41587-022-01532-7. Epub 2022 Nov 10. Nat Biotechnol. 2023. PMID: 36357717
Cytosine base editors (CBEs) efficiently generate precise C.G-to-T.A base conversions, but the activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (AID/APOBEC) protein family deaminase component induces considerable off-tar …
Cytosine base editors (CBEs) efficiently generate precise C.G-to-T.A base conversions, but the activation-induced cytidine deaminase/ …
The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer.
He J, Chai X, Zhang Q, Wang Y, Wang Y, Yang X, Wu J, Feng B, Sun J, Rui W, Ze S, Fu Y, Zhao Y, Zhang Y, Zhang Y, Liu M, Liu C, She M, Hu X, Ma X, Yang H, Li D, Zhao S, Li G, Zhang Z, Tian Z, Ma Y, Cao L, Yi B, Li D, Nussinov R, Eng C, Chan TA, Ruppin E, Gutkind JS, Cheng F, Liu M, Lu W. He J, et al. Among authors: li d. Nat Immunol. 2025 Mar;26(3):391-403. doi: 10.1038/s41590-024-02068-5. Epub 2025 Feb 4. Nat Immunol. 2025. PMID: 39905201
CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia.
Fu B, Liao J, Chen S, Li W, Wang Q, Hu J, Yang F, Hsiao S, Jiang Y, Wang L, Chen F, Zhang Y, Wang X, Li D, Liu M, Wu Y. Fu B, et al. Among authors: li d. Nat Med. 2022 Aug;28(8):1573-1580. doi: 10.1038/s41591-022-01906-z. Epub 2022 Aug 4. Nat Med. 2022. PMID: 35922667 Clinical Trial.
Both patients achieved transfusion independence for >18 months after treatment, and their Hb increased from 8.2 and 10.8 g dl(-1) at screening to 15.0 and 14.0 g dl(-1) at the last visit, respectively, with 85.46% and 89.48% editing persistence in bone marrow cel …
Both patients achieved transfusion independence for >18 months after treatment, and their Hb increased from 8.2 and 10.8 g dl(-1) …
Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD.
Xue N, Liu X, Zhang D, Wu Y, Zhong Y, Wang J, Fan W, Jiang H, Zhu B, Ge X, Gonzalez RVL, Chen L, Zhang S, She P, Zhong Z, Sun J, Chen X, Wang L, Gu Z, Zhu P, Liu M, Li D, Zhong TP, Zhang X. Xue N, et al. Among authors: li d. Nat Commun. 2023 Mar 3;14(1):1224. doi: 10.1038/s41467-023-36887-1. Nat Commun. 2023. PMID: 36869044 Free PMC article.
Base editors, including dual base editors, are innovative techniques for efficient base conversions in genomic DNA. However, the low efficiency of A-to-G base conversion at positions proximal to the protospacer adjacent motif (PAM) and the A/C simultaneous conversion of th …
Base editors, including dual base editors, are innovative techniques for efficient base conversions in genomic DNA. However, the low efficie …
Efficient mitochondrial A-to-G base editors for the generation of mitochondrial disease models.
Chen L, Hong M, Luan C, Yuan M, Wang Y, Guo X, Fang Y, Huang H, Dong X, Gao H, Zhang D, Chen X, Meng D, Huang M, Yi Z, Liu M, Wei W, Gao L, Song G, Zhou X, Li D. Chen L, et al. Among authors: li d. Nat Biotechnol. 2025 Jun 3. doi: 10.1038/s41587-025-02685-x. Online ahead of print. Nat Biotechnol. 2025. PMID: 40461783
Existing A-to-G base editors for mitochondrial DNA (mtDNA) are limited by low efficiency. We used directed evolution to discover variants of the TadA-8e base editors that have substantially increased activity and expanded targeting compatibility for both nuclear and mitoch …
Existing A-to-G base editors for mitochondrial DNA (mtDNA) are limited by low efficiency. We used directed evolution to discover vari …
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.
Luo J, Yang Z, Ma Y, Yue Z, Lin H, Qu G, Huang J, Dai W, Li C, Zheng C, Xu L, Chen H, Wang J, Li D, Siwko S, Penninger JM, Ning G, Xiao J, Liu M. Luo J, et al. Among authors: li d. Nat Med. 2016 May;22(5):539-46. doi: 10.1038/nm.4076. Epub 2016 Apr 11. Nat Med. 2016. PMID: 27064449
Herein we report that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL. ...
Herein we report that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for R …
Amelioration of metabolic and behavioral defects through base editing in the PahR408W phenylketonuria mouse model.
Yin S, Gao L, Sun X, Zhang M, Gao H, Chen X, Zhang D, Ming X, Yang L, Hu Y, Chen X, Liu M, Zhan X, Guan Y, Wang L, Han L, Zhu P, Li D. Yin S, et al. Among authors: li d. Mol Ther. 2025 Jan 8;33(1):119-132. doi: 10.1016/j.ymthe.2024.11.032. Epub 2024 Nov 26. Mol Ther. 2025. PMID: 39600089
Our findings revealed that a single intravenous injection in adult mice and a single intraperitoneal injection in neonatal mice resulted in 19.1%-34.6% A-to-G editing efficiency at the pathogenic mutation site with minimal bystander edits. Furthermore, the dual-AAV8-treate …
Our findings revealed that a single intravenous injection in adult mice and a single intraperitoneal injection in neonatal mice resulted in …
In vivo base editing rescues primary hyperoxaluria type 1 in rats.
Chen Z, Zhang D, Zheng R, Yang L, Huo Y, Zhang D, Fang X, Li Y, Xu G, Li D, Geng H. Chen Z, et al. Among authors: li d. Kidney Int. 2024 Mar;105(3):496-507. doi: 10.1016/j.kint.2023.11.029. Epub 2023 Dec 21. Kidney Int. 2024. PMID: 38142039
Adenine base editor (ABE) can precisely convert A.T to G.C with the assistance of specific guide RNA. Here, we demonstrated that systemic delivery of dual adeno-associated virus encoding a split-ABE8e could artificially repair 13% of the pathogenic allele in Agxt(Q84X) rat …
Adenine base editor (ABE) can precisely convert A.T to G.C with the assistance of specific guide RNA. Here, we demonstrated that syst …
49 results