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Year Number of Results
1919 1
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1947 1
1948 1
1949 1
1952 1
1954 5
1955 3
1956 9
1957 6
1958 7
1959 5
1960 19
1961 11
1962 22
1963 23
1964 25
1965 21
1966 24
1967 36
1968 36
1969 64
1970 50
1971 55
1972 55
1973 55
1974 66
1975 81
1976 79
1977 99
1978 91
1979 95
1980 109
1981 126
1982 143
1983 135
1984 141
1985 159
1986 191
1987 214
1988 218
1989 247
1990 278
1991 331
1992 355
1993 345
1994 410
1995 459
1996 531
1997 588
1998 674
1999 807
2000 978
2001 1060
2002 1189
2003 1392
2004 1706
2005 2049
2006 2335
2007 2508
2008 2877
2009 3263
2010 3721
2011 4143
2012 4707
2013 5148
2014 5739
2015 5959
2016 6089
2017 6170
2018 6517
2019 6722
2020 8104
2021 9001
2022 8499
2023 8213
2024 8173
2025 8393
2026 96

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118,169 results

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Page 1
LIM domain proteins in cell mechanobiology.
Anderson CA, Kovar DR, Gardel ML, Winkelman JD. Anderson CA, et al. Cytoskeleton (Hoboken). 2021 Jun;78(6):303-311. doi: 10.1002/cm.21677. Epub 2021 Jun 10. Cytoskeleton (Hoboken). 2021. PMID: 34028199 Free PMC article. Review.
Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity....
Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved me …
LIM homeodomain proteins and associated partners: Then and now.
Yasuoka Y, Taira M. Yasuoka Y, et al. Curr Top Dev Biol. 2021;145:113-166. doi: 10.1016/bs.ctdb.2021.04.003. Epub 2021 May 21. Curr Top Dev Biol. 2021. PMID: 34074528 Review.
This review focuses on one of those genes, Lim1/Lhx1, which encodes a transcription factor. Lim1/Lhx1 is a member of the LIM homeodomain (LIM-HD) protein family, and its intimate partner, Ldb1/NLI, binds to two tandem LIM domains of LIM-HDs. The most a …
This review focuses on one of those genes, Lim1/Lhx1, which encodes a transcription factor. Lim1/Lhx1 is a member of the LIM homeodom …
LIM domain proteins.
Dawid IB, Toyama R, Taira M. Dawid IB, et al. C R Acad Sci III. 1995 Mar;318(3):295-306. C R Acad Sci III. 1995. PMID: 7788499 Review.
In LIM homeodomain proteins, LIM domains seem to function as negative regulatory domains. LIM homeodomain proteins are involved in the control of cell lineage determination and the regulation of differentiation, and LIM-only proteins may have similar r …
In LIM homeodomain proteins, LIM domains seem to function as negative regulatory domains. LIM homeodomain proteins are …
LIM Kinases: From Molecular to Pathological Features.
Bénédetti H, Vallée B. Bénédetti H, et al. Cells. 2023 Jun 16;12(12):1649. doi: 10.3390/cells12121649. Cells. 2023. PMID: 37371119 Free PMC article.
LIM kinases (LIMKs), LIMK1 and LIMK2, are atypical kinases, as they are the only two members of the LIM kinase family harbouring two LIM domains at their N-terminus and a kinase domain at their C-terminus [...]....
LIM kinases (LIMKs), LIMK1 and LIMK2, are atypical kinases, as they are the only two members of the LIM kinase family harbouri …
LIM kinases: cofilin and beyond.
Prunier C, Prudent R, Kapur R, Sadoul K, Lafanechère L. Prunier C, et al. Oncotarget. 2017 Jun 20;8(25):41749-41763. doi: 10.18632/oncotarget.16978. Oncotarget. 2017. PMID: 28445157 Free PMC article. Review.
These last 10 years, several reports indicate that the functions of LIM kinases are more extended than initially described and, specifically, that LIM kinases also control microtubule dynamics, independently of their regulation of actin microfilament. In this review …
These last 10 years, several reports indicate that the functions of LIM kinases are more extended than initially described and, speci …
LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development.
Singh N, Singh D, Modi D. Singh N, et al. Sex Dev. 2022;16(2-3):147-161. doi: 10.1159/000518323. Epub 2021 Sep 10. Sex Dev. 2022. PMID: 34518474 Review.
LIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embryonic development. The activities of the LIM-HD proteins are regulated by the co-regulators LIM only (LMO) and LIM domai …
LIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embry …
PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development.
Jiang X, Xu Z, Jiang S, Wang H, Xiao M, Shi Y, Wang K. Jiang X, et al. Cancers (Basel). 2023 Oct 19;15(20):5042. doi: 10.3390/cancers15205042. Cancers (Basel). 2023. PMID: 37894409 Free PMC article. Review.
PDZ-LIM family proteins (PDLIMs) are a kind of scaffolding proteins that contain PDZ and LIM interaction domains. ...The structure and function of the PDZ and LIM structural domains and the role of the PDLIMs in tumor development are described....
PDZ-LIM family proteins (PDLIMs) are a kind of scaffolding proteins that contain PDZ and LIM interaction domains. ...The struc …
Small Molecules as LIM Kinase Inhibitors.
Bukhari SNA, Tandiary MA, Al-Sanea MM, Abdelgawad MA, Chee CF, Hussain MA. Bukhari SNA, et al. Curr Med Chem. 2022;29(17):2995-3027. doi: 10.2174/0929867328666211026120335. Curr Med Chem. 2022. PMID: 34702151 Review.
LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated …
LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of …
LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo.
Berabez R, Routier S, Bénédetti H, Plé K, Vallée B. Berabez R, et al. Cells. 2022 Jun 30;11(13):2090. doi: 10.3390/cells11132090. Cells. 2022. PMID: 35805176 Free PMC article. Review.
LIM Kinases are important actors in the regulation of cytoskeleton dynamics by controlling microtubule and actin filament turnover. ...The phosphorylation of cofilin to its inactive form by LIM kinases avoids actin filament depolymerization. The balance between phos …
LIM Kinases are important actors in the regulation of cytoskeleton dynamics by controlling microtubule and actin filament turnover. . …
LIM-domain-only proteins in cancer.
Matthews JM, Lester K, Joseph S, Curtis DJ. Matthews JM, et al. Nat Rev Cancer. 2013 Feb;13(2):111-22. doi: 10.1038/nrc3418. Epub 2013 Jan 10. Nat Rev Cancer. 2013. PMID: 23303138 Review.
LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implica …
LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particul …
118,169 results
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