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Page 1
A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD.
Irwin KE, Jasin P, Braunstein KE, Sinha IR, Garret MA, Bowden KD, Chang K, Troncoso JC, Moghekar A, Oh ES, Raitcheva D, Bartlett D, Miller T, Berry JD, Traynor BJ, Ling JP, Wong PC. Irwin KE, et al. Among authors: ling jp. Nat Med. 2024 Feb;30(2):382-393. doi: 10.1038/s41591-023-02788-5. Epub 2024 Jan 26. Nat Med. 2024. PMID: 38278991 Free PMC article.
Elevated nuclear TDP-43 induces constitutive exon skipping.
Carmen-Orozco RP, Tsao W, Ye Y, Sinha IR, Chang K, Trinh VT, Chung W, Bowden K, Troncoso JC, Blackshaw S, Hayes LR, Sun S, Wong PC, Ling JP. Carmen-Orozco RP, et al. Among authors: ling jp. Mol Neurodegener. 2024 Jun 9;19(1):45. doi: 10.1186/s13024-024-00732-w. Mol Neurodegener. 2024. PMID: 38853250 Free PMC article.
HnRNP L represses cryptic exons.
McClory SP, Lynch KW, Ling JP. McClory SP, et al. Among authors: ling jp. RNA. 2018 Jun;24(6):761-768. doi: 10.1261/rna.065508.117. Epub 2018 Mar 26. RNA. 2018. PMID: 29581412 Free PMC article.
Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis.
Britson KA, Ling JP, Braunstein KE, Montagne JM, Kastenschmidt JM, Wilson A, Ikenaga C, Tsao W, Pinal-Fernandez I, Russell KA, Reed N, Mozaffar T, Wagner KR, Ostrow LW, Corse AM, Mammen AL, Villalta SA, Larman HB, Wong PC, Lloyd TE. Britson KA, et al. Among authors: ling jp. Sci Transl Med. 2022 Jan 19;14(628):eabi9196. doi: 10.1126/scitranslmed.abi9196. Epub 2022 Jan 19. Sci Transl Med. 2022. PMID: 35044790 Free PMC article.
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
Sinha IR, Sandal PS, Spence H, Burns GD, Mallika AP, Abbasinejad F, Irwin KE, Cruz ALF, Wang V, Marx SR, Rodríguez JL, Langmead B, Gregory JM, Wong PC, Ling JP. Sinha IR, et al. Among authors: ling jp. Nat Commun. 2025 Jul 25;16(1):6878. doi: 10.1038/s41467-025-62004-5. Nat Commun. 2025. PMID: 40715064 Free PMC article.
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts.
Choi IY, Ling JP, Zhang J, Helmenstine E, Walter W, Tsakiroglou P, Bergman RE, Philippe C, Manley JL, Rouault-Pierre K, Li B, Wiseman DH, Batta K, Ouseph M, Bernard E, Dubner B, Li X, Haferlach T, Koget A, Fazal S, Jain T, Gocke CD, DeZern AE, Dalton WB. Choi IY, et al. Among authors: ling jp. Blood Adv. 2024 Aug 13;8(15):3961-3971. doi: 10.1182/bloodadvances.2023011260. Blood Adv. 2024. PMID: 38759096 Free PMC article.
37 results