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Page 1
Showing results for lc sf
Search for Llc SF instead (2 results)
When Critical View of Safety Fails: A Practical Perspective on Difficult Laparoscopic Cholecystectomy.
Alius C, Serban D, Bratu DG, Tribus LC, Vancea G, Stoica PL, Motofei I, Tudor C, Serboiu C, Costea DO, Serban B, Dascalu AM, Tanasescu C, Geavlete B, Cristea BM. Alius C, et al. Medicina (Kaunas). 2023 Aug 19;59(8):1491. doi: 10.3390/medicina59081491. Medicina (Kaunas). 2023. PMID: 37629781 Free PMC article. Review.
The incidence of common bile duct injuries following laparoscopic cholecystectomy (LC) remains three times higher than that following open surgery despite numerous attempts to decrease intraoperative incidents by employing better training, superior surgical instruments, im …
The incidence of common bile duct injuries following laparoscopic cholecystectomy (LC) remains three times higher than that following …
Discovery of LC-SF-14, a selective dual inhibitor of SHP2 and FGFR for the treatment of FGFR2-driven gastric cancer.
Zheng L, Wang Y, Jiang Z, Chen S, Cao X, Huang X, Luo R, Zheng L, Li Q, Tu L, Li J, Liang G, Chen L. Zheng L, et al. Eur J Med Chem. 2025 Sep 15;294:117745. doi: 10.1016/j.ejmech.2025.117745. Epub 2025 May 11. Eur J Med Chem. 2025. PMID: 40381223
In this study, we discovered a potent SHP2 and FGFR2 dual inhibitor, LC-SF-14, using a linked pharmacophore strategy and structural optimization. The active compound LC-SF-14 exhibited high inhibitory potency against both targets (71.6 nM and 8.9 nM, r …
In this study, we discovered a potent SHP2 and FGFR2 dual inhibitor, LC-SF-14, using a linked pharmacophore strategy and struc …
TMT-Based Quantitative Proteomics Analysis of Synovial Fluid-Derived Exosomes in Inflammatory Arthritis.
Huang Y, Liu Y, Huang Q, Sun S, Ji Z, Huang L, Li Z, Huang X, Deng W, Li T. Huang Y, et al. Front Immunol. 2022 Mar 11;13:800902. doi: 10.3389/fimmu.2022.800902. eCollection 2022. Front Immunol. 2022. PMID: 35359923 Free PMC article.
METHODS: Exosomes were separated from SF by the Exoquick kit combined ultracentrifugation method. Tandem mass tags (TMT)-labeled liquid chromatography mass spectrometry (LC-MS/MS) technology was used to analyze the proteomics of SF-derived exosomes. ...Enzyme …
METHODS: Exosomes were separated from SF by the Exoquick kit combined ultracentrifugation method. Tandem mass tags (TMT)-labeled liqu …
The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.
Cao L, Zhou Y, Lin S, Yang C, Guan Z, Li X, Yang S, Gao T, Zhao J, Fan N, Song Y, Li D, Li X, Li Z, Guan F, Tan Z. Cao L, et al. J Extracell Vesicles. 2024 Sep;13(9):e12499. doi: 10.1002/jev2.12499. J Extracell Vesicles. 2024. PMID: 39207047 Free PMC article.
Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer often associated with chronic hepatitis B virus infection (CHB) and liver cirrhosis (LC), underscoring the critical need for biomarker discovery to improve patient outcomes. ...Subsequently, we employed opt …
Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer often associated with chronic hepatitis B virus infection (CHB) and liver …
Evaluating facial dermis aging in healthy Caucasian females with LC-OCT and deep learning.
Assi A, Fischman S, Lopez C, Pedrazzani M, Grignon G, Missodey R, Korichi R, Cauchard JH, Ralambondrainy S, Bonnier F. Assi A, et al. Sci Rep. 2024 Oct 15;14(1):24113. doi: 10.1038/s41598-024-74370-z. Sci Rep. 2024. PMID: 39406771 Free PMC article.
Line Field Confocal Optical Coherence Tomography (LC-OCT) provides detailed 3D insights into various skin layers, including the papillary dermis and its fibrous network. In this study, a deep learning model utilizing a 3D ResNet-18 network was trained to predict chronologi …
Line Field Confocal Optical Coherence Tomography (LC-OCT) provides detailed 3D insights into various skin layers, including the papil …
Preservation of the fecal microbiome is associated with reduced severity of graft-versus-host disease.
Burgos da Silva M, Ponce DM, Dai A, M Devlin S, Gomes ALC, Moore G, Slingerland J, Shouval R, Armijo GK, DeWolf S, Fei T, Clurman A, Fontana E, Amoretti LA, Wright RJ, Andrlova H, Miltiadous O, Perales MA, Taur Y, Peled JU, van den Brink MRM. Burgos da Silva M, et al. Blood. 2022 Dec 1;140(22):2385-2397. doi: 10.1182/blood.2021015352. Blood. 2022. PMID: 35969834 Free PMC article.
Characteristics of locus coeruleus functional connectivity network in patients with comorbid migraine and insomnia.
Wang C, Chen S, Cheng Z, Xia S, Fei CJ, Ye L, Gong L, Xi C, Wang Y. Wang C, et al. J Headache Pain. 2024 Sep 27;25(1):159. doi: 10.1186/s10194-024-01877-1. J Headache Pain. 2024. PMID: 39333887 Free PMC article.
Lower FC between the LC and DLPFC was associated with greater insomnia severity, whereas higher FC between the LC and DMPFC was linked to longer migraine attack duration in the MI group. ...The identified LC-FC alterations may serve as potential targets for t …
Lower FC between the LC and DLPFC was associated with greater insomnia severity, whereas higher FC between the LC and DMPFC wa …
Decoding 11-oxygenated androgen synthesis: insights from enzyme gene expression and LC-MS/MS quantification.
Zheng J, Wang Y, Jiang J, Jin T, Liu Y, Guo Y, Chen Z, Su C, Wang H, Xie J, Guo B, Lv Y, Guo Y, Xie Y, Li M, Huang S, Liao J, Ye Y, Mo L, Yu Z, Huang L, Jiang Y, Mo Z. Zheng J, et al. Eur J Endocrinol. 2024 Aug 30;191(3):288-299. doi: 10.1093/ejendo/lvae104. Eur J Endocrinol. 2024. PMID: 39219353
To validate the findings, immunohistochemical and liquid chromatography-tandem mass spectrometry (LC-MS/MS) techniques were employed. RESULTS: Our investigation revealed that the gene expression levels of the enzymes HSD11B2 and AKR1C3 were notably elevated in the kidney a …
To validate the findings, immunohistochemical and liquid chromatography-tandem mass spectrometry (LC-MS/MS) techniques were employed. …
Single fraction radiosurgery, fractionated radiosurgery, and conventional radiotherapy for spinal oligometastasis (SAFFRON): A systematic review and meta-analysis.
Singh R, Lehrer EJ, Dahshan B, Palmer JD, Sahgal A, Gerszten PC, Zaorsky NG, Trifiletti DM. Singh R, et al. Radiother Oncol. 2020 May;146:76-89. doi: 10.1016/j.radonc.2020.01.030. Epub 2020 Feb 28. Radiother Oncol. 2020. PMID: 32114269
On subgroup analysis of de novo metastases, superior 1-year LC following SF-SRS (95.5% (95% CI: 87.4-99.6%)) was maintained compared to RT (83.6% (95% CI: 70.4-93.5%); p = 0.007). ...MF-SRS (9.6%; p = 0.039)) with no correlation between dose and VCF rates. CONCLUSIO …
On subgroup analysis of de novo metastases, superior 1-year LC following SF-SRS (95.5% (95% CI: 87.4-99.6%)) was maintained co …
Thermodynamic solubility measurement without chemical analysis.
Hokkala E, Strachan CJ, Agopov M, Järvinen E, Semjonov K, Heinämäki J, Yliruusi J, Svanbäck S. Hokkala E, et al. Int J Pharm. 2024 Mar 25;653:123890. doi: 10.1016/j.ijpharm.2024.123890. Epub 2024 Feb 10. Int J Pharm. 2024. PMID: 38346601 Free article.
In this work, the optical imaging based single particle analysis (SPA) and the gold standard shake-flask (SF) solubility methods are compared. We show that to analyze pharmaceutical compounds spanning 7 log units in solubility and a diverse chemical space with limited reso …
In this work, the optical imaging based single particle analysis (SPA) and the gold standard shake-flask (SF) solubility methods are …
1,007 results