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Page 1
Showing results for ligase a
Search for Lygas A instead (2 results)
RNA ligase ribozymes with a small catalytic core.
Nomura Y, Yokobayashi Y. Nomura Y, et al. Sci Rep. 2023 May 26;13(1):8584. doi: 10.1038/s41598-023-35584-9. Sci Rep. 2023. PMID: 37237056 Free PMC article.
Here, we explored simple and small ribozyme motifs capable of ligating two RNA fragments in a template-directed fashion (ligase ribozymes). One-round selection of small ligase ribozymes followed by deep sequencing revealed a ligase ribozyme motif comprising a …
Here, we explored simple and small ribozyme motifs capable of ligating two RNA fragments in a template-directed fashion (ligase riboz …
Horizontal acquisition of a DNA ligase improves DNA damage tolerance in eukaryotes.
Nicolas E, Simion P, Guérineau M, Terwagne M, Colinet M, Virgo J, Lingurski M, Boutsen A, Dieu M, Hallet B, Van Doninck K. Nicolas E, et al. Nat Commun. 2023 Nov 22;14(1):7638. doi: 10.1038/s41467-023-43075-8. Nat Commun. 2023. PMID: 37993452 Free PMC article.
A phylogenetic analysis reveals its orthology to prokaryotic DNA ligase E, and its horizontal acquisition by bdelloid rotifers and plausibly other eukaryotes. The fungus Mortierella verticillata, having a single copy of this DNA Ligase E homolog, also exhibits an in …
A phylogenetic analysis reveals its orthology to prokaryotic DNA ligase E, and its horizontal acquisition by bdelloid rotifers and pl …
R2D ligase: Unveiling a novel DNA ligase with surprising DNA-to-RNA ligation activity.
Gundesø SE, Rothweiler U, Heimland E, Piotrowski Y, Rødum IK, Söderberg JJ, Gábor IM, Solstad T, Williamson A, Lanes O, Striberny BK. Gundesø SE, et al. Biotechnol J. 2024 Mar;19(3):e2300711. doi: 10.1002/biot.202300711. Biotechnol J. 2024. PMID: 38528369
Here we report a novel DNA ligase from Cronobacter phage CR 9 (R2D Ligase) with an unexpected DNA-to-RNA ligation activity. The R2D ligase shows excellent efficiency when ligating DNA to either end of RNA molecules using a DNA template. ...
Here we report a novel DNA ligase from Cronobacter phage CR 9 (R2D Ligase) with an unexpected DNA-to-RNA ligation activity. Th …
Vypal2: A Versatile Peptide Ligase for Precision Tailoring of Proteins.
Zhang D, Wang Z, Hu S, Lescar J, Tam JP, Liu CF. Zhang D, et al. Int J Mol Sci. 2021 Dec 31;23(1):458. doi: 10.3390/ijms23010458. Int J Mol Sci. 2021. PMID: 35008882 Free PMC article.
Owing to their mild aqueous reaction conditions, enzymatic methods based on the use of peptide ligases are particularly desirable. In this regard, the recently discovered peptidyl Asx-specific ligases (PALs) have emerged as powerful biotechnological tools in recent …
Owing to their mild aqueous reaction conditions, enzymatic methods based on the use of peptide ligases are particularly desirable. In …
Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation.
Zhou L, O'Flaherty DK, Szostak JW. Zhou L, et al. J Am Chem Soc. 2020 Sep 16;142(37):15961-15965. doi: 10.1021/jacs.0c06722. Epub 2020 Sep 1. J Am Chem Soc. 2020. PMID: 32820909 Free PMC article.
DNA splints, splints with G:U wobble pairs, and splints with G to I (Inosine) substitutions all allowed for the efficient assembly of an active ribozyme ligase. Our work demonstrates the possibility of a transition from nonenzymatic ligation to enzymatic ligation and revea …
DNA splints, splints with G:U wobble pairs, and splints with G to I (Inosine) substitutions all allowed for the efficient assembly of an act …
Engineering a Catalytically Efficient Recombinant Protein Ligase.
Yang R, Wong YH, Nguyen GKT, Tam JP, Lescar J, Wu B. Yang R, et al. J Am Chem Soc. 2017 Apr 19;139(15):5351-5358. doi: 10.1021/jacs.6b12637. Epub 2017 Mar 1. J Am Chem Soc. 2017. PMID: 28199119
Unlike proteases that are abundantly available, fast-acting ligases are rare. OaAEP1 is an enzyme isolated from the cyclotide-producing plant oldenlandia affinis that displayed weak peptide cyclase activity, despite having a similar structural fold with other asparaginyl e …
Unlike proteases that are abundantly available, fast-acting ligases are rare. OaAEP1 is an enzyme isolated from the cyclotide-produci …
A synthetic peptide ligase.
Severin K, Lee DH, Kennan AJ, Ghadiri MR. Severin K, et al. Nature. 1997 Oct 16;389(6652):706-9. doi: 10.1038/39556. Nature. 1997. PMID: 9338780
First glance at the plant APC/C, a highly conserved ubiquitin-protein ligase.
Capron A, Okrész L, Genschik P. Capron A, et al. Trends Plant Sci. 2003 Feb;8(2):83-9. doi: 10.1016/S1360-1385(02)00028-6. Trends Plant Sci. 2003. PMID: 12597875 Review.
The anaphase-promoting complex or cyclosome (APC/C) is a cell-cycle-regulated ubiquitin-protein ligase that has been extensively studied in both fungal and animal cells. Many APC/C protein targets have been identified, and their sequential degradation during the cell cycle …
The anaphase-promoting complex or cyclosome (APC/C) is a cell-cycle-regulated ubiquitin-protein ligase that has been extensively stud …
Identifying and charactering a 4-aminobutyryl-CoA ligase for the production of butyrolactam.
Shen X, Jiang X, Sun X, Yuan Q, Wang J. Shen X, et al. J Biotechnol. 2024 Feb 20;382:21-27. doi: 10.1016/j.jbiotec.2024.01.005. Epub 2024 Jan 19. J Biotechnol. 2024. PMID: 38246203
Initially, a superior 4-aminobutyryl-CoA ligase was discovered and characterized among six acyl-CoA ligases from different sources, which greatly improved the pathway efficiency. ...
Initially, a superior 4-aminobutyryl-CoA ligase was discovered and characterized among six acyl-CoA ligases from different sou …
Butelase 1: A Versatile Ligase for Peptide and Protein Macrocyclization.
Nguyen GK, Kam A, Loo S, Jansson AE, Pan LX, Tam JP. Nguyen GK, et al. J Am Chem Soc. 2015 Dec 16;137(49):15398-401. doi: 10.1021/jacs.5b11014. Epub 2015 Dec 7. J Am Chem Soc. 2015. PMID: 26633100
We achieved cyclizations that are 20,000 times faster than sortase A, the most widely used ligase for protein cyclization. The reactions completed within minutes with up to 95% yields....
We achieved cyclizations that are 20,000 times faster than sortase A, the most widely used ligase for protein cyclization. The reacti …
129,752 results
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