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1838 1
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1842 1
1855 1
1861 1
1879 1
1880 1
1883 1
1885 1
1887 1
1901 1
1909 1
1910 1
1911 1
1912 3
1913 2
1914 2
1917 2
1918 1
1920 2
1921 1
1922 1
1923 2
1925 3
1926 3
1927 7
1928 8
1929 5
1930 6
1931 3
1932 4
1933 4
1934 1
1935 3
1936 1
1937 2
1938 3
1939 2
1940 1
1944 1
1945 15
1946 48
1947 69
1948 120
1949 106
1950 157
1951 210
1952 178
1953 217
1954 219
1955 238
1956 198
1957 179
1958 219
1959 145
1960 88
1961 106
1962 95
1963 104
1964 82
1965 246
1966 349
1967 455
1968 432
1969 439
1970 474
1971 515
1972 482
1973 510
1974 522
1975 564
1976 554
1977 608
1978 630
1979 624
1980 623
1981 688
1982 682
1983 745
1984 805
1985 841
1986 909
1987 1026
1988 985
1989 1107
1990 1165
1991 1146
1992 1073
1993 1187
1994 1335
1995 1328
1996 1472
1997 1478
1998 1699
1999 1620
2000 1913
2001 1933
2002 2028
2003 2128
2004 2115
2005 2304
2006 2456
2007 2650
2008 2852
2009 2935
2010 3282
2011 3509
2012 3817
2013 3990
2014 3974
2015 4121
2016 4177
2017 4164
2018 4354
2019 4299
2020 4712
2021 5173
2022 4971
2023 4831
2024 4652
2025 4343
2026 7

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114,002 results

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Page 1
Mitonuclear Compensatory Coevolution.
Hill GE. Hill GE. Trends Genet. 2020 Jun;36(6):403-414. doi: 10.1016/j.tig.2020.03.002. Epub 2020 Apr 11. Trends Genet. 2020. PMID: 32396834 Review.
In bilaterian animals, the mitochondrial genome is small, haploid, does not typically recombine, and is subject to accumulation of deleterious alleles via Muller's ratchet. These basic features of the genomic architecture present a paradox: mutational erosion of the …
In bilaterian animals, the mitochondrial genome is small, haploid, does not typically recombine, and is subject to accumulation of deleterio …
Apraclonidine-An eye opener.
Fierz FC, Disse LR, Bockisch CJ, Weber KP. Fierz FC, et al. Front Ophthalmol (Lausanne). 2022 Aug 9;2:902821. doi: 10.3389/fopht.2022.902821. eCollection 2022. Front Ophthalmol (Lausanne). 2022. PMID: 38983513 Free PMC article.
Moreover, apraclonidine was observed to have an elevating effect on the upper eyelid in Horner's syndrome as well as in healthy subjects, which is thought to be mediated by alpha-1 adrenergic receptors present in the Muller's muscle. We aim to quantitatively investi …
Moreover, apraclonidine was observed to have an elevating effect on the upper eyelid in Horner's syndrome as well as in healthy subjects, wh …
The Muller's Ratchet and Aging.
Govindaraju DR, Innan H, Veitia RA. Govindaraju DR, et al. Trends Genet. 2020 Jun;36(6):395-402. doi: 10.1016/j.tig.2020.02.004. Epub 2020 Mar 18. Trends Genet. 2020. PMID: 32396833 Review.
Such deleterious alterations, including epigenetic drift, irreversibly accumulate in a stepwise, ratchet-like manner and reduce cellular fitness, similar to the process known as Muller's ratchet. Here, we revisit the Muller's ratchet principle applied …
Such deleterious alterations, including epigenetic drift, irreversibly accumulate in a stepwise, ratchet-like manner and reduce cellular fit …
The Sutureless Mullerectomy.
Gildener-Leapman JR, Sheps I, Stein R, Benyamini O, Milstein A, Hartstein ME. Gildener-Leapman JR, et al. Ophthalmic Plast Reconstr Surg. 2019 May/Jun;35(3):290-293. doi: 10.1097/IOP.0000000000001331. Ophthalmic Plast Reconstr Surg. 2019. PMID: 30844915
PURPOSE: Muller's muscle-conjunctival resection (MMCR) is a well-known approach for ptosis repair. In its standard fashion, it involves resection of Muller's muscle and conjunctiva, followed by suturing of the conjunctiva and Muller's mus …
PURPOSE: Muller's muscle-conjunctival resection (MMCR) is a well-known approach for ptosis repair. In its standard fashion, it …
[Involutional ptosis].
Morax S. Morax S. J Fr Ophtalmol. 2006 Jun;29(6):703-11. doi: 10.1016/s0181-5512(06)76836-x. J Fr Ophtalmol. 2006. PMID: 16885903 French.
The typical clinical findings in aponeurotic defects are high or moderate ptosis, good to excellent levator function, thinning of the eyelid above the tarsus, high to absent lid crease, and normal Muller's muscle function. The purpose of the treatment is to repair t …
The typical clinical findings in aponeurotic defects are high or moderate ptosis, good to excellent levator function, thinning of the eyelid …
Muller's genetic load/species extinction hypothesis.
Calabrese EJ, Selby PB. Calabrese EJ, et al. Environ Res. 2024 Jan 15;241:117599. doi: 10.1016/j.envres.2023.117599. Epub 2023 Nov 10. Environ Res. 2024. PMID: 37952856 Review.
Two major mouse radiation research teams in the United States provided the most extensive tests of Muller's hypothesis. One group continued its study for more than two decades, over 82 consecutive generations, approximating 2500 human years. ...More recent data on i …
Two major mouse radiation research teams in the United States provided the most extensive tests of Muller's hypothesis. One gr …
OTULIN and Muller's morphs.
Spaan AN. Spaan AN. J Exp Med. 2024 Jun 3;221(6):e20240418. doi: 10.1084/jem.20240418. Epub 2024 Apr 23. J Exp Med. 2024. PMID: 38652463 Free PMC article.
Selective Interference and the Evolution of Sex.
Otto SP. Otto SP. J Hered. 2021 Mar 12;112(1):9-18. doi: 10.1093/jhered/esaa026. J Hered. 2021. PMID: 33047117 Review.
This selective interference underlies such phenomena as clonal interference and Muller's Ratchet and is broadly termed Hill-Robertson interference. In this review, I examine the potential for selective interference to account for the evolution and maintenance of sex …
This selective interference underlies such phenomena as clonal interference and Muller's Ratchet and is broadly termed Hill-Ro …
Bipedicle tarsoconjunctival flap.
Hargiss JL. Hargiss JL. Ophthalmic Plast Reconstr Surg. 1989;5(2):99-103. doi: 10.1097/00002341-198906000-00004. Ophthalmic Plast Reconstr Surg. 1989. PMID: 2487213
The difference from the Hughes flap is that the blood supply is maintained through two tubed pedicles of conjunctiva and Muller's muscle, rather than an apron of conjunctiva....
The difference from the Hughes flap is that the blood supply is maintained through two tubed pedicles of conjunctiva and Muller's …
Asexual Amoebae Escape Muller's Ratchet through Polyploidy.
Maciver SK. Maciver SK. Trends Parasitol. 2016 Nov;32(11):855-862. doi: 10.1016/j.pt.2016.08.006. Epub 2016 Sep 3. Trends Parasitol. 2016. PMID: 27599632 Free article. Review.
In the absence of sex, mutations are proposed to accumulate by a mechanism known as Muller's ratchet. I hypothesise that amoebae can escape the ravages of accumulated mutation by virtue of their being polyploid. ...
In the absence of sex, mutations are proposed to accumulate by a mechanism known as Muller's ratchet. I hypothesise that amoeb …
114,002 results
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