Murine leukemia virus long terminal repeat sequences can enhance gene activity in a cell-type-specific manner
- PMID: 3016518
- PMCID: PMC367022
- DOI: 10.1128/mcb.5.10.2832-2835.1985
Murine leukemia virus long terminal repeat sequences can enhance gene activity in a cell-type-specific manner
Abstract
We tested the ability of sequences in the long terminal repeat (LTR) of a mink cell focus-forming (MCF) murine leukemia virus to function as an enhancer in a cell-type-specific manner. In a stable transformation assay, the MCF or Akv LTR and the simian virus 40 enhancer had similar activities in murine fibroblasts. In contrast, the MCF LTR had a significantly greater activity in murine T lymphoid cells than did either the simian virus 40 enhancer or the Akv LTR.
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