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Comparative Study
. 1987 Apr;7(4):1559-62.
doi: 10.1128/mcb.7.4.1559-1562.1987.

Human retroviral sequences on the Y chromosome

J Silver, A Rabson, T Bryan, R Willey, M A Martin
Comparative Study

Human retroviral sequences on the Y chromosome

J Silver et al. Mol Cell Biol. 1987 Apr.

Abstract

Novel endogenous human retroviral sequences were cloned by low-stringency hybridization, using the pol gene of endogenous human retrovirus 51-1. One clone, lambda NP-2, contained gag, pol, env, and long terminal repeat sequences related to the corresponding portions of clone 51-1 and the closely related full-length endogenous human retrovirus 4-1. The sequence of the env gene of NP-2 was 73% homologous to that of 4-1. Genomic Southern blots of male and female DNAs showed that NP-2 is located on the Y chromosome and that the Y chromosome also contains one other sequence closely related to the env and 3' flanking regions of NP-2. Conservation of flanking DNA suggests that the second Y chromosome copy of the NP-2 env sequence arose by gene duplication rather than provirus insertion.

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References

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