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. 1986 May;83(10):3204-8.
doi: 10.1073/pnas.83.10.3204.

Murine myb protooncogene mRNA: cDNA sequence and evidence for 5' heterogeneity

T P Bender, W M Kuehl

Murine myb protooncogene mRNA: cDNA sequence and evidence for 5' heterogeneity

T P Bender et al. Proc Natl Acad Sci U S A. 1986 May.

Abstract

We have sequenced two overlapping cDNA clones from a murine pro-B cell library to generate a composite sequence that includes 3413 bases of the murine c-myb mRNA. There is a single long open reading frame, beginning at the first base of this sequence, and continuing from the first methionine codon at nucleotide 265 to a TGA termination codon at nucleotide 2173. The predicted murine translation product contains 636 amino acid residues and is about 71 kDa long, which is in good agreement with the 75-kDa molecular size determined for the avian c-myb protein. The murine c-myb protein shows a striking 82% amino acid homology in the region (amino acids 71-444) where it can be compared to the published avian c-myb gene sequence. S1 nuclease protection analysis indicates extreme heterogeneity at the 5' end of steady-state murine c-myb mRNA.

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