Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1988 Jul;170(7):3255-61.
doi: 10.1128/jb.170.7.3255-3261.1988.

Nucleotide sequence of the Clostridium acidiurici ("Clostridium acidi-urici") gene for 10-formyltetrahydrofolate synthetase shows extensive amino acid homology with the trifunctional enzyme C1-tetrahydrofolate synthase from Saccharomyces cerevisiae

T R Whitehead  1 , J C Rabinowitz
Affiliations
Comparative Study

Nucleotide sequence of the Clostridium acidiurici ("Clostridium acidi-urici") gene for 10-formyltetrahydrofolate synthetase shows extensive amino acid homology with the trifunctional enzyme C1-tetrahydrofolate synthase from Saccharomyces cerevisiae

T R Whitehead et al. J Bacteriol. 1988 Jul.

Abstract

The nucleotide sequence of the gene for 10-formyltetrahydrofolate synthetase (EC 6.3.4.3) from Clostridium acidiurici ("Clostridium acidi-urici") was determined. The synthetase mRNA initiation and termination regions were determined by primer extension and S1 nuclease mapping. Two potential -10 and -35 promoter regions were identified upstream of mRNA initiation. The terminator region was found to be in a large region of dyad symmetry. A comparison of the amino acid sequences of the monofunctional synthetase and the eucaryotic trifunctional enzyme, C1-tetrahydrofolate synthase, from Saccharomyces cerevisiae demonstrated a region of strong homology.

PubMed Disclaimer

References

    1. Annu Rev Genet. 1979;13:319-53 - PubMed
    1. Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 - PubMed
    1. J Biol Chem. 1972 Apr 10;247(7):1959-64 - PubMed
    1. J Biol Chem. 1984 Jan 25;259(2):1127-31 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Jun;84(12):3992-6 - PubMed

Publication types

MeSH terms

Associated data

LinkOut - more resources