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. 1988 Nov 15;156(3):1403-10.
doi: 10.1016/s0006-291x(88)80788-5.

Cloning, nucleotide sequence and molecular evolution of a rabbit processed metallothionein MT-2 pseudogene

Y C Tam  1 , M Hassan, A Chopra, J P Thirion
Affiliations

Cloning, nucleotide sequence and molecular evolution of a rabbit processed metallothionein MT-2 pseudogene

Y C Tam et al. Biochem Biophys Res Commun. .

Abstract

A rabbit metallothionein-2 pseudogene (MT-2 psi) has been isolated from a partial rabbit genomic library. Its unusual sequence shows evidence of complex rearrangements involving recombination and deletion events. There are no intervening sequences, 3' poly A tract or 5' regulatory DNA sequences. The pseudogene is flanked by two sets of direct repeats (CT)3 GT(CT)4 and CTGG(G)CTC. They are most probably the sites of insertion of MT-2 psi in the rabbit genome. In addition, a number of repetitive DNA sequences are observed flanking the MT-2 psi gene. These are features of a processed retrogene.

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