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Comparative Study
. 1990 Oct;178(2):573-8.
doi: 10.1016/0042-6822(90)90356-v.

Comparative sequence of the helper component (HC) region of potato virus Y and a HC-defective strain, potato virus C

D W Thornbury  1 , C A Patterson, J T Dessens, T P Pirone
Affiliations
Comparative Study

Comparative sequence of the helper component (HC) region of potato virus Y and a HC-defective strain, potato virus C

D W Thornbury et al. Virology. 1990 Oct.

Abstract

Potato virus C (PVC), a non-aphid transmissible strain of potato virus Y (PVY), was found to code for a protein (PVC-HC) which is similar in molecular weight and immunological reactivity to the helper component protein of PVY (PVY-HC). PVC-HC, however, was inactive with respect to its ability to effect aphid transmission of either PVC or PVY. The 5'-terminal 2.7-kb regions of PVC and PVY were sequenced. Within the HC region there was 92% nucleotide homology between the two strains; comparison of the derived amino acid sequences revealed 24 amino acid differences. Comparison of the PVC-HC sequence with that of five potyviruses revealed 2 amino acid changes which were specific to PVC-HC. These amino acids are prime targets for mutational analysis of HC activity.

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