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. 1992;35(5):324-31.
doi: 10.1007/BF00189895.

Alleles of the rat T-cell receptor beta chain gene complex

E P Blankenhorn  1 , P D Smith, C B Williams, G A Gutman
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Alleles of the rat T-cell receptor beta chain gene complex

E P Blankenhorn et al. Immunogenetics. 1992.

Abstract

Inbred rat strains provide a rich source of genetic diversity in immunologically relevant genes. We have characterized the alleles of one of these genes, encoding the rat T-cell receptor C beta 1 chain, by Southern blots and nucleic acid sequencing. The Cb1 gene segments from DA and LEW rats display complex allotypic variation: both coding and noncoding regions contain multiple nucleotide substitutions. In addition, there is a polymorphic insertion of a rat repetitive LINE element 3' to the coding region. The Cb1 alleles are one part of larger Tcrb haplotypes, containing V beta, D beta, and J beta elements; complete Cb1 genomic nucleotide sequences, and a partial list of the strain distribution of the two alleles, are described in this report.

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