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Comparative Study
. 1992 Feb;12(2):363-7.
doi: 10.1016/0888-7543(92)90386-7.

Rps4 maps near the inactivation center on the mouse X chromosome

R M Hamvas  1 , A Zinn, J T Keer, E M Fisher, P Beer-Romero, S D Brown, D C Page
Affiliations
Comparative Study

Rps4 maps near the inactivation center on the mouse X chromosome

R M Hamvas et al. Genomics. 1992 Feb.

Abstract

RPS4Y, a Y-linked gene in humans, appears to encode an isoform of ribosomal protein S4. A homologous locus on the human X chromosome, RPS4X, lies close to the X-inactivation center but fails to undergo X-inactivation. We have isolated a genomic clone from the mouse Rps4 locus, the homolog of human RPS4X. We derived an intron probe that hybridizes to the functional Rps4 locus but does not cross-hybridize to related sequences elsewhere in the mouse genome. Genetic mapping utilizing interspecific mouse backcrosses and the intron-specific probe demonstrates that Rps4 maps close to the Phka locus on the mouse X chromosome and in the vicinity of the X-inactivation center. The gene order Ccg-1-Rps4/Phka-Xist-Pgk-1 is conserved between mouse and human.

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