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. 1991 Oct 25;254(5031):579-80.
doi: 10.1126/science.1948036.

Cloning of a serotonin transporter affected by antidepressants

B J Hoffman  1 , E Mezey, M J Brownstein
Affiliations

Cloning of a serotonin transporter affected by antidepressants

B J Hoffman et al. Science. .

Abstract

A complementary DNA clone for a serotonin (5HT) transporter has been isolated from rat basophilic leukemia cells. The complementary DNA sequence predicts a 653-amino acid protein with 12 to 13 putative transmembrane domains. The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters. Uptake by CV-1 cells expressing the transporter complementary DNA resembles 5HT uptake by platelets and brain synaptosomes; it is sensitive to antidepressants, amphetamine derivatives, and cocaine.

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