Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1991 Nov 15;88(22):10138-42.
doi: 10.1073/pnas.88.22.10138.

Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element

P Leroy  1 , H Nakshatri, P Chambon
Affiliations
Comparative Study

Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element

P Leroy et al. Proc Natl Acad Sci U S A. .

Abstract

We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta 2 promoter. Moreover, RAR-alpha 2 and RAR-beta 2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-alpha 2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (alpha, beta, and gamma) bind in vitro.

PubMed Disclaimer

References

    1. EMBO J. 1991 Aug;10(8):2223-30 - PubMed
    1. Nature. 1990 Jan 11;343(6254):177-80 - PubMed
    1. EMBO J. 1991 May;10(5):1149-58 - PubMed
    1. EMBO J. 1991 Jan;10(1):71-81 - PubMed
    1. EMBO J. 1991 Jan;10(1):59-69 - PubMed

Publication types