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. 1992 May;188(1):391-5.
doi: 10.1016/0042-6822(92)90772-h.

Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes

A de Ronde  1 , B Klaver, W Keulen, L Smit, J Goudsmit
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Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes

A de Ronde et al. Virology. 1992 May.

Abstract

HIV-1 NEF genes were isolated directly from peripheral blood lymphocyte DNA of two HIV-1-infected individuals and cloned into an HXB-2-infectious molecular clone. The effect of NEF on virus production in T-cell lines and primary human lymphocytes was studied. Naturally occurring NEF accelerates virus production in primary human lymphocytes, but not in T-cell lines.

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