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. 1992 Jul;3(7):443-50.

Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity

R P Ryseck  1 , C Raynoschek, H Macdonald-Bravo, K Dorfman, M G Mattéi, R Bravo
Affiliations
  • PMID: 1419907

Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity

R P Ryseck et al. Cell Growth Differ. 1992 Jul.

Abstract

We have characterized a growth factor-inducible gene, pghs-B, isolated by differential screening of a lambda complementary DNA library from RNA of serum-stimulated NIH 3T3 cells which encodes a 604-amino acid protein presenting high similarity with prostaglandin G/H synthase (PGHS). Induction of both pghs-B mRNA and protein is rapid and remains at high levels for several hours. The increase in pghs-B mRNA is mainly due to transcriptional activation of the gene. PGHS-B has been expressed in the baculovirus system and has been demonstrated to be involved in prostaglandin synthesis and to be inhibited by indomethacin, demonstrating that PGHS-B is indeed an enzyme related to PGHS. The pghs-B gene maps to the [1G-1H2] region of the murine genome.

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