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Page 1
Tambjamines as Fast-Acting Multistage Antimalarials.
Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S, Winzeler EA, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P. Kumar A, et al. Among authors: madejczyk ms. ACS Infect Dis. 2024 Dec 13;10(12):4291-4300. doi: 10.1021/acsinfecdis.4c00659. Epub 2024 Nov 11. ACS Infect Dis. 2024. PMID: 39526703 Free PMC article.
Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
Dodean RA, Li Y, Zhang X, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Pou S, Winter RW, Liebman KM, Williams R, Kumar A, Chim-Ong A, Cui L, Orena S, Assimwe J, Tibagambirwa I, Byaruhanga O, Angutoko P, Legac J, Kreutzfeld O, Rosenthal PJ, Cooper RA, Nilsen A, Riscoe MK, Roth A, Kancharla P, Kelly JX. Dodean RA, et al. Among authors: madejczyk ms. J Med Chem. 2025 Apr 24;68(8):8817-8840. doi: 10.1021/acs.jmedchem.5c00419. Epub 2025 Apr 3. J Med Chem. 2025. PMID: 40179277 Free PMC article.
Potent Acridone Antimalarial against All Three Life Stages of Plasmodium.
Kancharla P, Dodean RA, Li Y, Zhang X, Kelly S, Charlton J, Binauhan A, Garcia L, Caridha D, Madejczyk MS, Jin X, Dennis WE, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Chimong A, Cui L, Vega-Rodriguez J, Okitwi M, Kreutzfeld O, Docan C, Green C, Liu Y, Agulay A, Mirsalis J, Farrell SN, McFadden GI, Goodman CD, Probst AS, Nilsen A, Catteruccia F, Rosenthal PJ, Riscoe M, Cooper R, Roth A, Kelly J. Kancharla P, et al. Among authors: madejczyk ms. Res Sq [Preprint]. 2025 Jun 27:rs.3.rs-6858328. doi: 10.21203/rs.3.rs-6858328/v1. Res Sq. 2025. PMID: 40678217 Free PMC article. Preprint.
Optimization of B-Ring-Functionalized Antimalarial Tambjamines and Prodiginines.
Kumar A, Chithanna S, Li Y, Zhang X, Dodean RA, Caridha D, Madejczyk MS, Lee PJ, Jin X, Chetree R, Blount C, Dennis WE, DeLuca J, Vuong C, Pannone K, Dinh HT, Leed S, Roth A, Reynolds KA, Kelly JX, Kancharla P. Kumar A, et al. Among authors: madejczyk ms. J Med Chem. 2024 Nov 14;67(21):19755-19776. doi: 10.1021/acs.jmedchem.4c02093. Epub 2024 Oct 19. J Med Chem. 2024. PMID: 39425665 Free PMC article.
Acridone Prodrugs with Enhanced Dual-Stage Antimalarial Efficacy.
Dodean RA, Li Y, Zhang X, Kumar A, Pou S, W Winter R, Liebman KM, Zakharov LN, Caridha D, Madejczyk MS, Vuong C, DeLuca J, Chin G, Kudyba K, McEnearney S, Jin X, Dennis WE, Chetree R, Blount C, Pannone K, Dinh HT, Mdaki K, Leed S, Lee PJ, Roth A, Kancharla P, Kelly JX. Dodean RA, et al. Among authors: madejczyk ms. ACS Med Chem Lett. 2025 Jun 6;16(7):1383-1390. doi: 10.1021/acsmedchemlett.5c00251. eCollection 2025 Jul 10. ACS Med Chem Lett. 2025. PMID: 40666482
Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents.
Kancharla P, Ortiz D, Fargo CM, Zhang X, Li Y, Sanchez M, Kumar A, Yeluguri M, Dodean RA, Caridha D, Madejczyk MS, Martin M, Jin X, Blount C, Chetree R, Pannone K, Dinh HT, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Dennis WE, Roncal N, Pybus BS, Lee PJ, Roth A, Reynolds KA, Kelly JX, Landfear SM. Kancharla P, et al. Among authors: madejczyk ms. J Med Chem. 2024 May 23;67(10):8323-8345. doi: 10.1021/acs.jmedchem.4c00517. Epub 2024 May 9. J Med Chem. 2024. PMID: 38722757 Free PMC article.
29 results