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Page 1
Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.
Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, Durand F, Gustot T, Saliba F, Domenicali M, Gerbes A, Wendon J, Alessandria C, Laleman W, Zeuzem S, Trebicka J, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL–CLIF Consortium. Moreau R, et al. Gastroenterology. 2013 Jun;144(7):1426-37, 1437.e1-9. doi: 10.1053/j.gastro.2013.02.042. Epub 2013 Mar 6. Gastroenterology. 2013. PMID: 23474284
The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.
Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Janicko M, Steib C, Reiberger T, Acevedo J, Gatti P, Bernal W, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Bendtsen F, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solè C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Özdogan OC, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Curto A, Pitarch C, Putignano A, Moreno E, Shawcross D, Aguilar F, Clària J, Ponzo P, Jansen C, Vitalis Z, Zaccherini G, Balogh B, Vargas V, Montagnese S, Alessandria C, Bernardi M, Ginès P, Jalan R, Moreau R, Angeli P, Arroyo V; PREDICT STUDY group of the EASL-CLIF Consortium. Trebicka J, et al. J Hepatol. 2020 Oct;73(4):842-854. doi: 10.1016/j.jhep.2020.06.013. Epub 2020 Jul 13. J Hepatol. 2020. PMID: 32673741 Free article.
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.
Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jansen C, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Jarcuska P, Steib C, Reiberger T, Acevedo J, Gatti P, Shawcross DL, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Danielsen KV, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solé C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Kani HT, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia-Lopez E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Praktiknjo M, Curto A, Pitarch C, Putignano A, Moreno E, Bernal W, Aguilar F, Clària J, Ponzo P, Vitalis Z, Zaccherini G, Balogh B, Gerbes A, Vargas V, Alessandria C, Bernardi M, Ginès P, Moreau R, Angeli P, Jalan R, Arroyo V; PREDICT STUDY group of the EASL-CLIF CONSORTIUM. Trebicka J, et al. J Hepatol. 2021 May;74(5):1097-1108. doi: 10.1016/j.jhep.2020.11.019. Epub 2020 Nov 20. J Hepatol. 2021. PMID: 33227350 Free article.
Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure.
Clària J, Stauber RE, Coenraad MJ, Moreau R, Jalan R, Pavesi M, Amorós À, Titos E, Alcaraz-Quiles J, Oettl K, Morales-Ruiz M, Angeli P, Domenicali M, Alessandria C, Gerbes A, Wendon J, Nevens F, Trebicka J, Laleman W, Saliba F, Welzel TM, Albillos A, Gustot T, Benten D, Durand F, Ginès P, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL-CLIF Consortium and the European Foundation for the Study of Chronic Liver Failure (EF-CLIF). Clària J, et al. Hepatology. 2016 Oct;64(4):1249-64. doi: 10.1002/hep.28740. Epub 2016 Aug 25. Hepatology. 2016. PMID: 27483394 Free article.
Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure.
Jalan R, Saliba F, Pavesi M, Amoros A, Moreau R, Ginès P, Levesque E, Durand F, Angeli P, Caraceni P, Hopf C, Alessandria C, Rodriguez E, Solis-Muñoz P, Laleman W, Trebicka J, Zeuzem S, Gustot T, Mookerjee R, Elkrief L, Soriano G, Cordoba J, Morando F, Gerbes A, Agarwal B, Samuel D, Bernardi M, Arroyo V; CANONIC study investigators of the EASL-CLIF Consortium. Jalan R, et al. J Hepatol. 2014 Nov;61(5):1038-47. doi: 10.1016/j.jhep.2014.06.012. Epub 2014 Jun 17. J Hepatol. 2014. PMID: 24950482
Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis.
Trebicka J, Aguilar F, Queiroz Farias A, Lozano JJ, Sánchez-Garrido C, Usón-Raposo E, de la Peña-Ramirez C, Sidorova J, Curto-Vilalta A, Sierra-Casas P, Momoyo Zitelli P, Papp M, Pereira G, Caraceni P, Goncalves LL, Alessandria C, Torre A, Laleman W, Gadano A, Piano S, Mattos AZ, Gu W, Brol MJ, Schierwagen R, Uschner FE, Fischer J, Mendes LSC, Vargas V, Alvares-da-Silva MR, Mookerjee R, Bittencourt PL, Benitez C, Albillos A, Couto C, Mendizabal M, Bañares R, Toledo CL, Mazo DF, Janicko M, Castillo-Barradas M, Padilla Machaca PM, Gatti P, Miranda AZ, Malé-Velázquez R, Zipprich A, Castro-Lyra A, Gustot T, Bernal W, Gerbes AL, Jalan R, Fernández J, Angeli P, Carrilho FJ, Claria J, Moreau R, Arroyo V; PREDICT study and ACLARA study. Trebicka J, et al. Gut. 2025 Jul 7;74(8):1293-1307. doi: 10.1136/gutjnl-2024-333876. Gut. 2025. PMID: 40011033 Free article.
Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies.
Luo J, Hu M, Feng T, Zhang L, Huang Y, Huang Y, Ye F, Li J, Aguilar F, Sánchez-Garrido C, Usón-Raposo E, Zhu B, Zhou Q, Liang X, Li J, Li P, Xin J, Shi D, Zheng J, Zhang H, Wang B, Qiang W, Yao H, Zhou X, Chen J, Hu W, Li B, Ma S, Wu X, Li X, Kong Y, Sun F, Chen X, Wu T, Yang L, Sun S, Guo B, He L, Chen J, Xin S, Li X, Chen H, Angeli P, Jalan R, Lin B, Chen Y, You S, Chen X, Queiroz Farias A, Trebicka J, Jiang J, Moreau R, Li J; CANONIC, PREDICT, ACLARA Study Group; Chinese Group on the Study of Severe Hepatitis B (COSSH). Luo J, et al. Gut. 2025 Aug 7:gutjnl-2025-335651. doi: 10.1136/gutjnl-2025-335651. Online ahead of print. Gut. 2025. PMID: 40713188 Free article.
Ipilimumab and nivolumab in advanced hepatocellular carcinoma after failure of prior immune checkpoint inhibitor-based combination therapies: a multicenter retrospective study.
Roessler D, Öcal O, Philipp AB, Markwardt D, Munker S, Mayerle J, Jochheim LS, Hammer K, Lange CM, Geier A, Seidensticker M, Reiter FP, De Toni EN, Ben Khaled N. Roessler D, et al. Among authors: markwardt d. J Cancer Res Clin Oncol. 2023 Jul;149(7):3065-3073. doi: 10.1007/s00432-022-04206-8. Epub 2022 Jul 21. J Cancer Res Clin Oncol. 2023. PMID: 35864269 Free PMC article.
Should routine risk reduction procedures for the prevention and control of pandemics become a standard in all oncological outpatient clinics? The prospective COVID-19 cohort study: protect-CoV.
Fey T, Erickson N, Stahler A, Muenchhoff M, Keppler OT, Ruehlmann K, Krauss-Pfeiffer G, Steinberg H, Graf A, Krebs S, Blum H, Khatamzas E, Seynstahl S, Casuscelli J, Markwardt D, Forstpointner R, Schinköthe T, von Bergwelt-Baildon M, Heinemann V. Fey T, et al. Among authors: markwardt d. Med Oncol. 2022 Apr 10;39(6):104. doi: 10.1007/s12032-022-01700-4. Med Oncol. 2022. PMID: 35397689 Free PMC article.
25 results