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Targeted temperature management at 33°C versus 36°C after cardiac arrest.
Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H; TTM Trial Investigators. Nielsen N, et al. N Engl J Med. 2013 Dec 5;369(23):2197-206. doi: 10.1056/NEJMoa1310519. Epub 2013 Nov 17. N Engl J Med. 2013. PMID: 24237006 Free article. Clinical Trial.
Standardized EEG interpretation accurately predicts prognosis after cardiac arrest.
Westhall E, Rossetti AO, van Rootselaar AF, Wesenberg Kjaer T, Horn J, Ullén S, Friberg H, Nielsen N, Rosén I, Åneman A, Erlinge D, Gasche Y, Hassager C, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wetterslev J, Wise MP, Cronberg T; TTM-trial investigators. Westhall E, et al. Neurology. 2016 Apr 19;86(16):1482-90. doi: 10.1212/WNL.0000000000002462. Epub 2016 Feb 10. Neurology. 2016. PMID: 26865516 Free PMC article. Clinical Trial.
Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial.
Moseby-Knappe M, Levin H, Ullén S, Zetterberg H, Blennow K, Lagebrant A, Dankiewicz J, Jakobsen JC, Lilja G, Nichol AD, Eastwood G, Ainscough K, Thomas MJC, Grejs AM, Keeble TR, Rylander C, Düring J, Wise MP, Hovdenes J, Storm C, Borgquist O, Cariou A, Deye N, Lascarrou JB, Bannard-Smith J, Undén J, Vignon P, Legriel S, Šmíd O, Pogson D, Karasek J, McGuigan PJ, Joannidis M, Kirkegaard H, Bewley J, Christensen S, Maccaroni MR, Valerianova A, Lundin A, Lybeck A, Leithner C, Varhaník F, Sweet K, Walden A, Friberg H, Cronberg T, Nielsen N; TTM2 biobank study investigators. Moseby-Knappe M, et al. Lancet Respir Med. 2025 Dec 11:S2213-2600(25)00363-7. doi: 10.1016/S2213-2600(25)00363-7. Online ahead of print. Lancet Respir Med. 2025. PMID: 41391459
Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design.
Nielsen N, Wetterslev J, al-Subaie N, Andersson B, Bro-Jeppesen J, Bishop G, Brunetti I, Cranshaw J, Cronberg T, Edqvist K, Erlinge D, Gasche Y, Glover G, Hassager C, Horn J, Hovdenes J, Johnsson J, Kjaergaard J, Kuiper M, Langørgen J, Macken L, Martinell L, Martner P, Pellis T, Pelosi P, Petersen P, Persson S, Rundgren M, Saxena M, Svensson R, Stammet P, Thorén A, Undén J, Walden A, Wallskog J, Wanscher M, Wise MP, Wyon N, Aneman A, Friberg H. Nielsen N, et al. Among authors: martinell l. Am Heart J. 2012 Apr;163(4):541-8. doi: 10.1016/j.ahj.2012.01.013. Am Heart J. 2012. PMID: 22520518 Clinical Trial.