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Year Number of Results
1801 1
1803 1
1814 1
1827 1
1830 1
1836 1
1838 1
1845 1
1849 1
1893 1
1926 1
1927 2
1928 2
1929 2
1930 3
1931 6
1934 2
1935 2
1940 1
1951 3
1952 4
1961 1
1962 1
1963 1
1965 1
1966 1
1967 1
1971 3
1972 11
1973 30
1974 29
1975 27
1976 21
1977 1
1978 8
1979 2
1980 1
1981 3
1982 1
1983 3
1984 4
1985 4
1986 10
1987 3
1988 5
1989 8
1990 9
1991 6
1992 11
1993 21
1994 18
1995 31
1996 53
1997 83
1998 90
1999 102
2000 112
2001 139
2002 151
2003 142
2004 159
2005 188
2006 221
2007 209
2008 245
2009 252
2010 286
2011 305
2012 319
2013 415
2014 453
2015 554
2016 579
2017 559
2018 579
2019 586
2020 669
2021 807
2022 862
2023 873
2024 924
2025 799
2026 1

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10,661 results

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Page 1
Macrophage-derived chemokine (MDC).
Mantovani A, Gray PA, Van Damme J, Sozzani S. Mantovani A, et al. J Leukoc Biol. 2000 Sep;68(3):400-4. J Leukoc Biol. 2000. PMID: 10985257 Review.
Macrophage-derived chemokine (MDC) is a CC chemokine paradigmatic of emerging aspects of chemokine immunobiology. It is constitutively expressed, yet microbial products and cytokines regulate its expression with divergent effects of type II (IL-4 and IL-13) and type I (int …
Macrophage-derived chemokine (MDC) is a CC chemokine paradigmatic of emerging aspects of chemokine immunobiology. It is constitutivel …
Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19.
Korobova ZR, Arsentieva NA, Totolian AA. Korobova ZR, et al. Int J Mol Sci. 2023 Aug 23;24(17):13083. doi: 10.3390/ijms241713083. Int J Mol Sci. 2023. PMID: 37685890 Free PMC article.
Macrophage-derived chemokine (MDC/CCL22) is a chemokine of the C-C subfamily. It is involved in T-cellular maturation and migration. ...Additionally, we present our explanations for the observed decrease in MDC/CCL22 concentrations in COVID-19. The first hypothesis …
Macrophage-derived chemokine (MDC/CCL22) is a chemokine of the C-C subfamily. It is involved in T-cellular maturation and migration. …
Regulation of macrophage-derived chemokine (MDC, CCL22) production.
Yamashita U, Kuroda E. Yamashita U, et al. Crit Rev Immunol. 2002;22(2):105-14. Crit Rev Immunol. 2002. PMID: 12433129 Review.
MDC-production is also upregulated by prostaglandin and cyclic AMP-elevating agents. MDC causes chemotactic migration of dendritic cells and TH2 cells. Furthermore, MDC is highly-expressed in the lesions of TH2-related diseases, such as airway hypersensitivit …
MDC-production is also upregulated by prostaglandin and cyclic AMP-elevating agents. MDC causes chemotactic migration of dendr …
Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan.
Rodriguez Lanzi C, Wei R, Luo D, Mackenzie GG. Rodriguez Lanzi C, et al. Neoplasia. 2022 Feb;24(2):133-144. doi: 10.1016/j.neo.2021.12.004. Epub 2021 Dec 27. Neoplasia. 2022. PMID: 34968866 Free PMC article.
In addition, we evaluated whether MDC-22 could synergize with current chemotherapeutic drugs used in the clinic. MDC-22 reduced the growth of various human pancreatic cancer cell lines in a concentration-dependent manner. ...In both models, MDC-22 inhibited E …
In addition, we evaluated whether MDC-22 could synergize with current chemotherapeutic drugs used in the clinic. MDC-22 reduce …
Endobolome, a New Concept for Determining the Influence of Microbiota Disrupting Chemicals (MDC) in Relation to Specific Endocrine Pathogenesis.
Aguilera M, Gálvez-Ontiveros Y, Rivas A. Aguilera M, et al. Front Microbiol. 2020 Nov 30;11:578007. doi: 10.3389/fmicb.2020.578007. eCollection 2020. Front Microbiol. 2020. PMID: 33329442 Free PMC article. Review.
These MDC might have the ability to promote specific changes in the microbiota that can ultimately result in common intestinal and chronic or long-term systemic diseases in the host. ...In any case, further animal controlled experiments, clinical trials and large epidemiol …
These MDC might have the ability to promote specific changes in the microbiota that can ultimately result in common intestinal and ch …
The phospholipids cardiolipin and phosphatidylethanolamine differentially regulate MDC biogenesis.
Xiao T, English AM, Wilson ZN, Maschek JA, Cox JE, Hughes AL. Xiao T, et al. J Cell Biol. 2024 May 6;223(5):e202302069. doi: 10.1083/jcb.202302069. Epub 2024 Mar 18. J Cell Biol. 2024. PMID: 38497895 Free PMC article.
CL depletion impairs MDC biogenesis, whereas blocking mitochondrial PE production leads to constitutive MDC formation. ...Altogether, our data indicate a requirement for CL in MDC biogenesis and suggest that PE depletion may stimulate MDC formation dow …
CL depletion impairs MDC biogenesis, whereas blocking mitochondrial PE production leads to constitutive MDC formation. ...Alto …
Amino acids trigger MDC-dependent mitochondrial remodeling by altering mitochondrial function.
Raghuram N, Hughes AL. Raghuram N, et al. bioRxiv [Preprint]. 2024 Jul 12:2024.07.09.602707. doi: 10.1101/2024.07.09.602707. bioRxiv. 2024. PMID: 39026767 Free PMC article. Preprint.
We show that amino acid-activation of MDCs is dependent on the functional state of mitochondria. While amino acid excess triggers MDC formation when cells are grown on fermentable carbon sources, stimulating mitochondrial biogenesis blocks MDC formation. ...These re …
We show that amino acid-activation of MDCs is dependent on the functional state of mitochondria. While amino acid excess triggers MDC …
The MDC family of proteins and their processing during epididymal transit.
Frayne J, Jury JA, Barker HL, Hall L. Frayne J, et al. J Reprod Fertil Suppl. 1998;53:149-55. J Reprod Fertil Suppl. 1998. PMID: 10645274 Review.
All members of the MDC family of integral membrane proteins contain a metalloproteinase-like domain, a disintegrin-like domain and a cysteine-rich domain. ...It is possible that the additional MDC proteins expressed on macaque spermatozoa may also be involved in thi …
All members of the MDC family of integral membrane proteins contain a metalloproteinase-like domain, a disintegrin-like domain and a …
Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation.
Luo D, Fraga-Lauhirat M, Millings J, Ho C, Villarreal EM, Fletchinger TC, Bonfiglio JV, Mata L, Nemesure MD, Bartels LE, Wang R, Rigas B, Mackenzie GG. Luo D, et al. Carcinogenesis. 2019 Dec 31;40(12):1480-1491. doi: 10.1093/carcin/bgz069. Carcinogenesis. 2019. PMID: 30994173 Free PMC article.
In this study, we explored the anticancer efficacy of MDC-1112 in preclinical models of GBM, and evaluated its mode of action. MDC-1112 inhibited the growth of multiple human GBM cell lines in a concentration- and time-dependent manner. Normal human astrocytes were …
In this study, we explored the anticancer efficacy of MDC-1112 in preclinical models of GBM, and evaluated its mode of action. MDC …
Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine.
Luo D, Digiovanni MG, Wei R, Lacomb JF, Williams JL, Rigas B, Mackenzie GG. Luo D, et al. Carcinogenesis. 2020 Jul 14;41(7):927-939. doi: 10.1093/carcin/bgz170. Carcinogenesis. 2020. PMID: 31584613 Free PMC article.
We have previously shown that phospho-valproic acid (MDC-1112) is effective in cell-line xenografts of PC. Here, we explored whether MDC-1112 is effective in additional clinically relevant animal models of PC and whether MDC-1112 enhances the anticancer effec …
We have previously shown that phospho-valproic acid (MDC-1112) is effective in cell-line xenografts of PC. Here, we explored whether …
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