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Year Number of Results
1946 1
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1991 3
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1999 1
2002 1
2003 1
2004 1
2008 2
2009 1
2010 2
2012 2
2013 7
2014 2
2015 6
2016 4
2017 4
2018 5
2019 7
2020 7
2021 8
2022 6
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88 results

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Page 1
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang YJ, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Kargbo-Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colón-Mercado JM, Reyes JF, Ryan VH, Nelson MP, Cook CN, Li Z, Screven L, Kwan JY, Mehta PR, Zanovello M, Hallegger M, Shantaraman A, Ping L, Koike Y, Oskarsson B, Staff NP, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Reich DS, Rohrer JD, Malaspina A, Dickson DW, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME. Seddighi S, et al. Among authors: mehta pr. Sci Transl Med. 2024 Feb 14;16(734):eadg7162. doi: 10.1126/scitranslmed.adg7162. Epub 2024 Feb 14. Sci Transl Med. 2024. PMID: 38277467 Free PMC article.
Creation of de novo cryptic splicing for ALS and FTD precision medicine.
Wilkins OG, Chien MZYJ, Wlaschin JJ, Barattucci S, Harley P, Mattedi F, Mehta PR, Pisliakova M, Ryadnov E, Keuss MJ, Thompson D, Digby H, Knez L, Simkin RL, Diaz JA, Zanovello M, Brown AL, Darbey A, Karda R, Fisher EMC, Cunningham TJ, Le Pichon CE, Ule J, Fratta P. Wilkins OG, et al. Among authors: mehta pr. Science. 2024 Oct 4;386(6717):61-69. doi: 10.1126/science.adk2539. Epub 2024 Oct 3. Science. 2024. PMID: 39361759 Free PMC article.
Genotype, extrapyramidal features, and severity of variant ataxia-telangiectasia.
Schon K, van Os NJH, Oscroft N, Baxendale H, Scoffings D, Ray J, Suri M, Whitehouse WP, Mehta PR, Everett N, Bottolo L, van de Warrenburg BP, Byrd PJ, Weemaes C, Willemsen MA, Tischkowitz M, Taylor AM, Hensiek AE. Schon K, et al. Among authors: mehta pr. Ann Neurol. 2019 Feb;85(2):170-180. doi: 10.1002/ana.25394. Ann Neurol. 2019. PMID: 30549301 Free PMC article.
TDP-43 loss induces cryptic polyadenylation in ALS/FTD.
Bryce-Smith S, Brown AL, Chien MZYJ, Dattilo D, Mehta PR, Mattedi F, Barattucci S, Mikheenko A, Zanovello M, Pellegrini F, El-Agamy SE, Yome M, Hill SE, Qi YA, Sun K, Ryadnov E, Wan Y; NYGC ALS Consortium; Vargas JNS, Birsa N, Raj T, Humphrey J, Keuss M, Wilkins OG, Ward M, Secrier M, Fratta P. Bryce-Smith S, et al. Among authors: mehta pr. Nat Neurosci. 2025 Nov;28(11):2190-2200. doi: 10.1038/s41593-025-02050-w. Epub 2025 Oct 21. Nat Neurosci. 2025. PMID: 41120751 Free PMC article.
Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs.
Keuss MJ, Harley P, Ryadnov E, Jackson RE, Zanovello M, Wilkins OG, Barattucci S, Mehta PR, Oliveira MG, Parkes JE, Sinha A, Correa-Sánchez AF, Oliver PL, Fisher EMC, Schiavo G, Shah M, Burrone J, Fratta P. Keuss MJ, et al. Among authors: mehta pr. bioRxiv [Preprint]. 2024 Jun 24:2024.06.20.599684. doi: 10.1101/2024.06.20.599684. bioRxiv. 2024. PMID: 38979232 Free PMC article. Preprint.
The era of cryptic exons: implications for ALS-FTD.
Mehta PR, Brown AL, Ward ME, Fratta P. Mehta PR, et al. Mol Neurodegener. 2023 Mar 15;18(1):16. doi: 10.1186/s13024-023-00608-5. Mol Neurodegener. 2023. PMID: 36922834 Free PMC article. Review.
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.
Joseph BJ, Marshall KA, Harley P, Mann JR, Alessandrini F, Vanoye CG, Chi W, Prudencio M, Simkin D, Kao TT, Desai RR, Keuss MJ, Barattucci S, Zanovello M, Mehta PR, DeKeyser JM, Limone F, Lee J, Brown AL, Leyton-Jaimes MF, Nash LA, Juan IGS, Aronica E, Wainger BJ, Shah M, Goswami A, Shneider NA, Dickson DW, Burrone J, Zhang C, Wichterle H, Petrucelli L, Watts JK, George AL Jr, Fratta P, Eggan K, Kiskinis E. Joseph BJ, et al. Among authors: mehta pr. Nat Neurosci. 2025 Dec;28(12):2476-2492. doi: 10.1038/s41593-025-02096-w. Epub 2025 Oct 31. Nat Neurosci. 2025. PMID: 41174170 Free PMC article.
Grey Matter Etymology and the neuron(e).
Mehta AR, Mehta PR, Anderson SP, MacKinnon BLH, Compston A. Mehta AR, et al. Among authors: mehta pr. Brain. 2020 Jan 1;143(1):374-379. doi: 10.1093/brain/awz367. Brain. 2020. PMID: 31844876 Free PMC article.
88 results